花提取物在预防雄性小鼠高脂血症和肝脏脂质过氧化中的作用

Anand Kar, Yasha J Jha, D. Mahar
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摘要

:高脂血症会导致冠心病。虽然他汀类药物是常规使用的药物,但往往会产生副作用。现在,我们尝试研究花朵(MOF)提取物在调节雄性小鼠由tyloxapol诱发的高脂血症和组织脂质过氧化反应(LPO)中的作用。实验共分六组,Ⅰ组为对照组,Ⅱ组为高脂血症对照组,接受泰乐沙醇(300 毫克/千克,单剂量,14 天一次)治疗,Ⅲ组接受辛伐他汀(300 毫克/千克,单剂量,14 天一次)治疗。第三组服用辛伐他汀(200 毫克/千克),第四、第五和第六组每天分别服用 400、200 和 100 毫克/千克的 MOF 提取物,连续服用 15 天。这四组(III-VI)还在第 14 天服用了相同剂量的泰乐沙醇。第 16 天,分析血清总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白和极低密度脂蛋白的变化;肝脏 LPO、超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶和肝脏组织学变化。还估算了总酚和类黄酮的含量。通过 DPPH 和 HO 试验检测了体外抗氧化性:结果表明,除高密度脂蛋白外,MOF 治疗的高脂血症小鼠血清中的其他脂质均明显降低,肝脏 LPO 同时降低,抗氧化剂增加。组织学研究也表明,预处理 MOF 可减少肝损伤。我们认为,花提取物可通过抗氧化作用改善高脂血症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of flower extract in preventing hyperlipidemia and liver lipid peroxidation in male mice
: Hyperlipidemia leads to coronary artery disease. Although statins are used conventionally, they are often associated with side effects. It has now been attempted to study the role of flower (MOF) extract in the regulation of tyloxapol-induced hyperlipidemia and tissue lipid peroxidation (LPO) in male mice.Six groups of animals were taken. Group I acted as control and group II, receiving tyloxapol (300 mg/kg, single dose on 14 day) served as hyperlipidemic control. Group III received simvastatin (200 mg/kg), while group IV, V and VI received MOF extract at 400, 200 and 100 mg/kg every day respectively for 15 days. These four groups (III- VI) also received same amount of tyloxapol on 14 day. On day 16 changes in the serum total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein and very low-density lipoprotein; hepatic LPO, super oxide dismutase, catalase, glutathione peroxidase and histological changes in liver were analyzed. Total phenolic and flavonoid contents were also estimated. The in-vitro antioxidative property was checked through DPPH and HO assays.: Results showed significant reduction in all the serum lipids except HDL, which was increased in MOF treated hyperlipidemic mice, with the parallel decrease in hepatic LPO and increase in antioxidants. Histological studies also showed reduction in hepatic damage with the pre-treatment of MOF. However, the most effective dose was found to be 400 mg/kg of MOF. : We suggest that flower extract may ameliorate hyperlipidemia with antioxidative benefits.
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