钦奈人群自身免疫性甲状腺炎的抗甲状腺抗体谱和病毒标记物

Vasanthy Nagarajan, Sarah Andrea Wilson, Kaveri Krishansamy, Banumathi Radhika
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摘要

自身免疫性甲状腺疾病(AITD)是遗传和环境因素复杂相互作用的结果,它导致一种或多种控制甲状腺反应性T细胞和B细胞的机制失效。临床上最常见的自身免疫性甲状腺炎包括桥本氏甲状腺炎和格雷夫病。病毒与自身免疫性疾病的发病有关。本研究旨在通过评估有自身免疫性甲状腺炎临床表现的病例的病毒学和免疫学参数,研究自身免疫性甲状腺炎与病毒之间的关联。采用酶联免疫吸附法评估了抗甲状腺过氧化物酶(TPO)和抗甲状腺球蛋白(TG)抗体。采用 ELISA 方法评估丙型肝炎病毒(HCV)IgG 抗体和 IgM 抗体。通过 RT-PCR 检测是否存在 RNA。共有六十名研究对象参与了这项研究。其中,16 名男性患者(26.66%)和 44 名女性患者(68.33%)的抗 TPO 抗体呈阳性。四名男性患者(6.66%)和二十五名女性患者(41.66%)抗 TG 抗体呈阳性。4 名男性患者(6.66%)和 22 名女性患者(36.66%)抗TPO 和抗 TG 抗体均呈阳性。一名女性患者的 HCV IgG 抗体检测呈阳性。通过 ELISA 检测,16 名患者(26.66%)的 IgM 呈阳性,其中 3 名男性患者(5%)和 13 名女性患者(21.66%)。没有一个样本的 RNA 呈阳性。我们的结论是,病毒感染可能参与触发自身免疫机制。要确定HCV与自身免疫性甲状腺疾病发病机制之间的关联,还需要对更多人群进行进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antithyroid antibody profile and viral markers in autoimmune thyroiditis in Chennai population
Autoimmune thyroid disease (AITD) is the result of a complex interaction between genetic and environmental factors, which leads to failure of one or more mechanisms responsible for controlling thyroid-reactive T and B cells. The most frequently occurring clinical forms of autoimmune thyroiditis include Hashimoto’s thyroiditis and Grave’s disease. Viruses have been implicated in the onset of autoimmune disorders. This study aims to investigate the association between and in autoimmune thyroiditis by assessing virologic and immunologic parameters of cases with clinical indication of AITD. Anti-thyroid peroxidase (TPO) and Anti-thyroglobulin (TG) antibodies were evaluated using ELISA. The presence of Hepatitis C virus (HCV) IgG antibodies and IgM antibodies were evaluated using ELISA. The presence of RNA was investigated by RT-PCR. A total of sixty study subjects were involved in this study. Sixteen male patients (26.66%) and forty-four female patients (68.33%) were positive for Anti-TPO antibodies. Four male patients (6.66%) and twenty-five female patients (41.66%) were positive for Anti-TG antibodies. Four male patients (6.66%) and twenty-two female patients (36.66%) were positive for both Anti-TPO and Anti-TG antibodies. One female patient tested positive for HCV IgG antibodies. Sixteen patients (26.66%) were positive for IgM by ELISA of which 3 patients (5%) were male and 13 patients (21.66%) were female. None of the samples were positive for RNA. We conclude that viral infection may be involved in triggering autoimmune mechanisms. Further studies with a larger population are necessary to establish an association between HCV, and in the pathogenesis of autoimmune thyroid disorders.
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