在伤口愈合切口模型中,染料木苷苷元苷元可促进皮肤恢复:在卵巢切除大鼠中与雷洛昔芬和雌二醇进行比较

Hari Prasad Sonwani
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引用次数: 0

摘要

背景和目标:伤口愈合不良通常与更年期雌激素耗竭有关。有关使用染料木素的抗衰老化妆品配方的实验得出了有关皮肤健康的有趣发现。在此,我们研究了在切口伤口愈合模型中全身给药的染料木苷苷元与全身给药的雌二醇和雷洛昔芬的效果对比。实验方法:将卵巢切除术(OVX)六个月后的大鼠随机分为 12 组,每组 12 只,每天给予盐酸雷洛昔芬(0.05 和 0.5 mg-kg-1s.c.)、染料木苷苷元(1 和 10 mg-kg-1s.c.)或 17-a-ethinyl estradiol(0.003 和 0.03 mg-kg-1s.c.)治疗,为期 12 周。卵巢切除大鼠和假卵巢切除大鼠未接受治疗,作为对照组。然后,在实验结束前 14 天或 7 天进行切口伤口愈合技术,并收集皮肤标本以评估分子、组织学和功能测量结果。重要结果与假性 OVX 动物的样本相比,OVX 大鼠的样本在伤口愈合 7 天和 14 天后显示出转化生长因子-b1、组织转谷氨酰胺酶 2 和血管内皮生长因子的减少。染料木素、雷洛昔芬和雌二醇都在很大程度上改变了这种下降趋势,但最低剂量的染料木素比其他两种疗法的影响更大。此外,在增强伤口拉伸强度和皮肤愈合方面,最佳的染料木素剂量是最低剂量。推论和结论:控制皮肤伤口愈合的一种潜在替代疗法是染料木素苷元。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
In An Incisional Model of Wound Healing, Genistein Aglycone Enhances Skin Recovery: A Comparison with Raloxifene and Estradiol in Ovariectomized Rats Is Presented
Context and goal: Poor wound healing is commonly associated with estrogen depletion during menopause. Experiments on anti-aging cosmetic formulations using genistein have yielded intriguing findings about skin health. Here, we examined the effects of systemically administered the genistein aglycones in an incisional wound healing model in comparison to systemically administered estradiol and raloxifene. Method of experimentation: Rats were randomly divided into groups of 12 animals each six months after Ovariectomies (OVX) and given daily treatments of raloxifene hydrochloride (0.05 and 0.5 mg·kg-1s.c.), genistein aglycone (1 and 10 mg·kg-1s.c.) or 17-a-ethinyl estradiol (0.003 and 0.03 mg·kg-1s.c.) for a period of 12 weeks. Rats with OVX and sham OVX were not treated and served as controls. Then, an incisional wound healing technique was carried out 14 or 7 days before to the experiment’s conclusion and skin specimens were gathered to assess molecular, histological and functional measurements. Important Results: Compared to samples from sham OVX animals, samples from OVX rats seven and fourteen days after wounding shown a decrease in transforming growthfactor-b1, tissue transglutaminase 2 and vascular endothelial growth factor. Genistein, raloxifene and estradiol all considerably altered this decline, but the lowest dose of genistein had a stronger impact than the other two therapies. Furthermore, the best genistein dosage for enhancing wound tensile strength and skin healing was the lowest one. Inferences and conclusions: One potential alternative treatment for the control of skin wound healing is genistein aglycone.
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