Male Hyperuricemia Is Associated with Poor Reproductive Outcomes of IVF-ET

Objective. To investigate the effect of male hyperuricemia on reproductive outcome of in vitro fertilization-embryo transfer (IVF-ET). Methods. Clinical data of 412 couples who underwent their first cycle of IVF-ET were analyzed. According to the serum uric acid (SUA) level of the male, they were divided into control group (SUA ≤ 416 μmol/L) and hyperuricemia group (SUA > 416 μmol/L). The primary and secondary observation indices were pregnancy outcome after quality fresh embryo transfer and embryo outcome after IVF. Binary logistic regression was used to analyze the relationship between male SUA and related pregnancy outcomes. The ROC curve of the effect of male SUA on biochemical pregnancy loss rate (BPLR) after fresh embryo transplantation was drawn. Results. BPLR in hyperuricemia group increased significantly than that in control group (4.7% vs. 31.6%, P = 0.012), and the clinical pregnancy rate and live birth rate were significantly lower (61.5% vs. 39.4%, P = 0.038) (56.9% vs. 33.3%, P = 0.027). Binary logistic regression analysis showed that BPLR after fresh embryo transfer was positively correlated with male SUA (B = 0.010, P = 0.019, OR = 1.010, 95% CI (1.002, 1.018)). The area under receiver operating characteristic curve was 0.784, the specificity was 53.7%, and the sensitivity was 100.0%, P = 0.010. Moreover, the total fertilization rate and 2PN fertilization rate in hyperuricemia group were significantly lower than those in control group (86.0% vs. 81.6%, P = 0.001) (75.0% vs. 69.6%, P  < 0.001). Conclusion. Male hyperuricemia is an independent risk factor for increasing BPLR after fresh embryo transfer and can also reduce the total fertilization rate and 2PN fertilization rate of IVF.