缺血缺氧时的费舍尔低聚肽比值：补充苏醒素和褪黑素的预防性修正作用

IF 2.4 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Future Science OA Pub Date : 2024-01-17 DOI:10.2144/fsoa-2023-0117

Mai O Kadry, H. Ali

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引用次数: 0

摘要

目的：缺血缺氧的基本病理生理学是氧耗竭。费舍尔比值对监测缺氧强度至关重要。方法：本研究强调了苏醒素（QRC）和/或褪黑素（MLN）对亚硝酸钠（SN）脑缺氧的预防作用。研究结果预防性治疗前，先用亚硝酸钠（60 毫克/千克，S.C.）诱导缺氧。亚硝酸钠会降低血红蛋白（Hb），升高 HIF-α、HSP-70、IL-6 和 TNF-α。槐黄素和/或 MLN 恢复了已改善的炎症生物标志物，调节了去甲肾上腺素、多巴胺、5-羟色胺和γ-氨基丁酸（GABA）。同样，单细胞凝胶电泳（SCGE 或 COMET）DNA 损伤检测也证实了这一发现。结论通过舒泊汀和 MLN 治疗是改善亚硝酸钠诱导的脑损伤的最有效疗法。

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Fischer's oligopeptide ratio in ischemic hypoxia: prophylactic amendment of sophoretin and melatonin supplementation

Aim: The fundamental pathophysiology of ischemic-hypoxia is oxygen depletion. Fischer's ratio is essential for monitoring hypoxia intensity. Methods: the current study highlighted the prophylactic role of sophoretin (QRC) and/or melatonin (MLN) versus sodium nitrite (SN) brain hypoxia. Results: Prophylactic treatment with sophoretin and MLN, was preceded with hypoxia-induction via sodium nitrite (60 mg/kg, S.C.). SN decreased hemoglobin (Hb), elevated HIF-α, HSP-70, IL-6 and TNF-α. Sophoretin and/or MLN restored the ameliorated inflammatory biomarkers, modulated norepinephrine, dopamine, serotonin and gamma-aminobutyric acid (GABA). Similarly, single-cell gel electrophoresis (SCGE or COMET) DNA-damage assay confirmed this finding. Conclusion: Treatment via sophoretin and MLN was the most effective therapy for improving sodium nitrite induced brain injury.

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来源期刊

Future Science OA MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

5.00

自引率

4.00%

发文量

审稿时长

13 weeks

期刊介绍： Future Science OA is an online, open access, peer-reviewed title from the Future Science Group. The journal covers research and discussion related to advances in biotechnology, medicine and health. The journal embraces the importance of publishing all good-quality research with the potential to further the progress of research in these fields. All original research articles will be considered that are within the journal''s scope, and have been conducted with scientific rigour and research integrity. The journal also features review articles, editorials and perspectives, providing readers with a leading source of commentary and analysis. Submissions of the following article types will be considered: -Research articles -Preliminary communications -Short communications -Methodologies -Trial design articles -Trial results (including early-phase and negative studies) -Reviews -Perspectives -Commentaries