韩国社区居住的非吸烟成年人中二手烟与骨折风险的关系

IF 3.4 Q2 ENDOCRINOLOGY & METABOLISM
JBMR Plus Pub Date : 2024-01-21 DOI:10.1093/jbmrpl/ziae010
Junyeong Ahn, H. Park, Sung Joon Cho, Seungjin Baek, Yumie Rhee, N. Hong
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引用次数: 0

摘要

尽管主动吸烟对骨骼健康的有害影响已被广泛认可,但二手烟暴露对非吸烟者骨折风险的影响仍不甚了解。研究人员分析了 4843 名 40-69 岁的非吸烟者,他们参加了 2001 年至 2018 年的韩国基因组与流行病学研究。根据参与者的二手烟暴露状况,将他们分为两组:目前暴露组和未暴露组。暴露组随后根据每周暴露时间的中位数分为两个亚组(高组和低组)。新骨折的发生率是通过自我报告的问卷调查确定的。已确定的骨折根据骨折部位进行分类:整体骨折、椎体骨折、髋部骨折、非椎体骨折和非椎体非髋部骨折。参与者的平均年龄为 52.4 岁(84.1% 为女性)。在对年龄、性别、体重指数、家庭收入、胫骨中轴骨密度、c 反应蛋白、饮酒量和骨折史等多个协变量进行调整后,暴露于二手烟与骨折风险增加有关(调整后危险比 [aHR]:1.27,P = 0.028)。二手烟仍然是导致骨折的重要风险因素,与使用骨折风险评估工具估算的主要骨质疏松性骨折概率无关(aHR:1.24,P = 0.038)。高暴露组的骨折风险高于未暴露组(aHR:1.33,P = 0.025),而低暴露组和未暴露组的骨折风险差异不大(aHR:1.18,P = 0.253),这表明可能存在剂量反应关系。二手烟与非椎体骨折(aHR:1.37,P = 0.008)或非椎体非髋部骨折(aHR:1.36,P = 0.013)风险增加密切相关,而二手烟与椎体骨折的关系减弱(aHR:1.03,P = 0.908)。二手烟与非吸烟者骨折风险升高有关,与临床风险因素无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of secondhand smoke with fracture risk in community-dwelling non-smoking adults in Korea
Although the detrimental effects of active smoking on bone health have been widely recognized, the impact of secondhand smoke exposure on fracture risk in non-smokers remains less understood. A total of 4843 non-smokers aged 40–69 years, who participated in the Korean Genome and Epidemiology Study from 2001 to 2018, were analyzed. The participants were categorized into two groups based on their exposure status to secondhand smoke: currently exposed and unexposed. The exposure group was subsequently divided into two subgroups based on the median weekly exposure time (high versus low groups). The incidence of new fractures was determined using self-reported questionnaires. The identified fractures were categorized according to the fracture site: overall, vertebral, hip, non-vertebral, and non-vertebral non-hip fractures. The mean age of the participants was 52.4 years (84.1% women). Exposure to secondhand smoke was associated with an increased risk of fracture (adjusted hazard ratio [aHR]: 1.27, P = 0.028) after adjusting for multiple covariates including age, sex, body mass index, household income, bone density of mid-shaft tibia, c-reactive protein, alcohol consumption, and history of fracture. Secondhand smoke remained as a significant risk factor for fracture, independent of the major osteoporotic fracture probabilities estimated using a fracture risk assessment tool (aHR: 1.24, P = 0.038). The high exposure group had higher risk of fracture than that of the unexposed group (aHR: 1.33, P = 0.025) whereas the fracture risk did not differ significantly between low exposure and unexposed groups (aHR: 1.18, P = 0.253), suggesting a potential dose–response relationship. Secondhand smoke showed robust association with increased risk of non-vertebral (aHR: 1.37, P = 0.008) or non-vertebral non-hip fractures (aHR: 1.36, P = 0.013), while its association with vertebral fracture was attenuated (aHR: 1.03, P = 0.908). Secondhand smoke was associated with an elevated risk of fracture in non-smokers, independent of clinical risk factors.
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来源期刊
JBMR Plus
JBMR Plus Medicine-Orthopedics and Sports Medicine
CiteScore
5.80
自引率
2.60%
发文量
103
审稿时长
8 weeks
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