机械力介导的癌细胞与成纤维细胞之间的相互作用及其在肝细胞癌进展过程中的作用

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-22 DOI:10.20517/2394-4722.2023.137

Zheng Peng, Yanling Ding, Hongyu Zhang, Xia Meng, Yiyong Huang, Pengfei Zhang, Zepeng Li, Xiaoling Zhou

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引用次数: 0

摘要

机械力在癌症的发生和发展过程中起着关键作用。成纤维细胞和癌细胞之间的细胞间相互作用在肿瘤组织中产生了很大一部分机械力。因此，鉴于各种实体瘤的治疗进展缓慢，迫切需要进一步研究癌细胞和成纤维细胞之间由机械力介导的细胞间相互作用。在之前的研究中，我们利用细胞培养模型观察到肝细胞癌（HCC）细胞和成纤维细胞之间通过整合素和 ECM 蛋白进行的明显的机械力介导的相互作用，并发现这些相互作用在三维结构形成和肿瘤生长中发挥着重要作用，这表明它们在 HCC 治疗中具有潜在的应用价值。在这篇综述中，我们总结了这一领域的最新研究进展，希望能为潜在抗癌策略的开发提供启示，并特别关注 HCC。

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Mechanical force-mediated interactions between cancer cells and fibroblasts and their role in the progression of hepatocellular carcinoma

Mechanical forces play a key role in the initiation and progression of cancer. Intercellular interactions between fibroblasts and cancer cells contribute a large portion of the mechanical forces in tumor tissue. Hence, further investigation of the mechanical force-mediated intercellular interactions between cancer cells and fibroblasts is urgently needed, given the slow progress in the management of various solid cancers. In our previous study, we observed obvious mechanical force-mediated interactions between hepatocellular carcinoma (HCC) cells and fibroblasts through integrins and ECM proteins by using our coculture model and discovered that these interactions play important roles in 3D structure formation and tumor growth, suggesting their potential application in HCC treatment. In this review, we summarize the recent research progress in this field in hopes of providing insight into the development of potential anticancer strategies, with a special focus on HCC.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.