加纳某大都市 COVID-19 患者的血液学特征和 ACE2 水平

COVID Pub Date : 2024-01-23 DOI:10.3390/covid4020011
E. B. Ackah, M. Owusu, B. Sackey, Justice K. Boamah, J. S. Kamasah, Albert A. Aduboffour, Debora Akortia, Gifty Nkrumah, Andrews Amaniampong, Nicholas Klevor, Lawrence D. Agyemang, N. K. Ayisi-Boateng, A. Sylverken, Richard O. Phillips, E. Owusu-Dabo
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Nasopharyngeal swabs were taken to test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and blood samples were collected for complete blood count testing, ABO/Rhesus typing, and assessment of plasma ACE2 levels. Demographic and COVID-19 severity data were gathered, and IBM SPSS version 25.0 was used for analysis. Results: Overall, 515 patients were enrolled, out of which 55.9% (n = 288/515) were males and 50.3% (n = 259/515) tested positive for SARS-CoV-2. The median age was 37 years (IQR = 26–53). Age was significantly associated with SARS-CoV-2 infection (p = 0.002). The severe COVID-19 group was the oldest (70 years, IQR = 35–80) and presented with anaemia (haemoglobin, g/dL: 9.55, IQR = 7.85–11.93), leukocytosis (WBC × 103/μL: 15.87, IQR = 6.68–19.80), neutrophilia (NEUT × 106/μL: 14.69, IQR = 5.70–18.96) and lymphocytopenia (LYMPH × 106/μL: 0.47, IQR = 0.22–0.66). No association was found between SARS-CoV-2 positivity and ABO (p = 0.711) or Rh (p = 0.805) blood groups; no association was also found between plasma ACE2 levels and SARS-CoV-2 status (p = 0.079). However, among COVID-19 participants, plasma ACE2 levels were significantly reduced in the moderate illness group (40.68 ng/mL, IQR = 34.09–48.10) compared with the asymptomatic group (50.61 ng/mL, IQR = 43.90–58.61, p = 0.015). Conclusions: While there may be no real association between the ABO blood group, as well as plasma ACE2 levels, and SARS-CoV-2 infection in Ghanaian patients, older individuals are at a higher risk of severe disease. 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引用次数: 0

摘要

背景:多项研究表明,2019年冠状病毒病(COVID-19)的风险与年龄和ABO血型有关。血浆血管紧张素转换酶 2 (ACE2) 水平和血细胞计数的变化也有报道,这表明疾病的严重程度与低淋巴细胞水平有关。目的:本研究旨在了解这些因素与加纳患者 COVID-19 的关系,同时考虑到地域和人口统计学差异。研究方法2020 年 6 月至 2021 年 7 月期间,从加纳库马西的六家医院招募参与者。采集鼻咽拭子以检测严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2),采集血样以检测全血细胞计数、ABO/瑞氏分型和评估血浆 ACE2 水平。收集了人口统计学和 COVID-19 严重程度数据,并使用 IBM SPSS 25.0 版进行分析。结果共有 515 名患者入组,其中 55.9%(n = 288/515)为男性,50.3%(n = 259/515)SARS-CoV-2 检测呈阳性。年龄中位数为 37 岁(IQR = 26-53)。年龄与 SARS-CoV-2 感染明显相关(p = 0.002)。严重的 COVID-19 组年龄最大(70 岁,IQR = 35-80),表现为贫血(血红蛋白,g/dL:9.55,IQR = 7.85-11.93)、白细胞增多(WBC × 103/μL:15.87,IQR = 6.68-19.80)、中性粒细胞增多(NEUT × 106/μL:14.69,IQR = 5.70-18.96)和淋巴细胞减少(LYMPH × 106/μL:0.47,IQR = 0.22-0.66)。SARS-CoV-2 阳性与 ABO 血型(p = 0.711)或 Rh 血型(p = 0.805)之间没有关联;血浆 ACE2 水平与 SARS-CoV-2 状态之间也没有关联(p = 0.079)。然而,在 COVID-19 参与者中,与无症状组(50.61 纳克/毫升,IQR = 43.90-58.61,p = 0.015)相比,中度疾病组(40.68 纳克/毫升,IQR = 34.09-48.10)的血浆 ACE2 水平显著降低。结论虽然加纳病人的 ABO 血型和血浆 ACE2 水平与 SARS-CoV-2 感染之间可能没有真正的联系,但年龄较大的人罹患严重疾病的风险较高。贫血和白细胞增多伴淋巴细胞减少可能是病情恶化的指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Haematological Profile and ACE2 Levels of COVID-19 Patients in a Metropolis in Ghana
Background: Several studies have linked coronavirus disease 2019 (COVID-19) risk to age and ABO blood groups. Variations in plasma angiotensin-converting enzyme 2 (ACE2) levels and blood counts have been reported, suggesting an association between disease severity and low lymphocyte levels. Aim: this study aimed to understand how these factors relate to COVID-19 in Ghanaian patients, considering geographical and demographic differences. Methods: Participants were recruited from six hospitals in Kumasi, Ghana, between June 2020 and July 2021. Nasopharyngeal swabs were taken to test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and blood samples were collected for complete blood count testing, ABO/Rhesus typing, and assessment of plasma ACE2 levels. Demographic and COVID-19 severity data were gathered, and IBM SPSS version 25.0 was used for analysis. Results: Overall, 515 patients were enrolled, out of which 55.9% (n = 288/515) were males and 50.3% (n = 259/515) tested positive for SARS-CoV-2. The median age was 37 years (IQR = 26–53). Age was significantly associated with SARS-CoV-2 infection (p = 0.002). The severe COVID-19 group was the oldest (70 years, IQR = 35–80) and presented with anaemia (haemoglobin, g/dL: 9.55, IQR = 7.85–11.93), leukocytosis (WBC × 103/μL: 15.87, IQR = 6.68–19.80), neutrophilia (NEUT × 106/μL: 14.69, IQR = 5.70–18.96) and lymphocytopenia (LYMPH × 106/μL: 0.47, IQR = 0.22–0.66). No association was found between SARS-CoV-2 positivity and ABO (p = 0.711) or Rh (p = 0.805) blood groups; no association was also found between plasma ACE2 levels and SARS-CoV-2 status (p = 0.079). However, among COVID-19 participants, plasma ACE2 levels were significantly reduced in the moderate illness group (40.68 ng/mL, IQR = 34.09–48.10) compared with the asymptomatic group (50.61 ng/mL, IQR = 43.90–58.61, p = 0.015). Conclusions: While there may be no real association between the ABO blood group, as well as plasma ACE2 levels, and SARS-CoV-2 infection in Ghanaian patients, older individuals are at a higher risk of severe disease. Anaemia, and leukocytosis with lymphocytopenia may be indicators of poor disease progression.
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