间充质干细胞外泌体：一种用于胶质瘤治疗的前景广阔的输送系统

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-24 DOI:10.1515/oncologie-2023-0482

Tianfei Ma, Gang Su, Qionghui Wu, Minghui Shen, Xinli Feng, Zhen-chang Zhang

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引用次数: 0

摘要

胶质瘤具有高侵袭性、频繁复发和高死亡率，因此尤其具有挑战性。尽管有手术、放疗和化疗等治疗方法，但每种方法都面临着很大的局限性。因此，人们迫切需求针对胶质瘤的新策略。在这种情况下，间充质干细胞（MSCs）近年来显示出了巨大的潜力。然而，间充质干细胞在胶质瘤治疗中的应用遇到了各种挑战。间充质干细胞的关键分泌物--外泌体（Exo）的利用是这一领域的一大进步。这些外泌体不仅具有间充质干细胞固有的优点，还表现出独特的理化特性，使其成为有效的药物载体。因此，间充质干细胞外泌体作为一种专为胶质瘤治疗而设计的先进给药系统，正逐渐得到认可。间充质干细胞 Exo 不仅仅是一种创新的给药机制，它还显示出作为一种独立疗法的潜力。本文旨在详细总结间叶干细胞外溶液在胶质瘤发展过程中的重要作用，以及它作为药物输送载体在对抗这种可怕疾病中日益增长的重要性。

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Mesenchymal stem cell exosomes: a promising delivery system for glioma therapy

Gliomas are particularly challenging due to their high invasiveness, frequent recurrence, and elevated mortality rates. Despite the availability of treatments like surgery, radiation, and chemotherapy, each of these methods faces significant limitations. This has led to a pressing demand for new strategies against gliomas. In this landscape, mesenchymal stem cells (MSCs) have shown significant potential in recent years. However, the application of MSCs in glioma therapy encounters various challenges. A significant advancement in this field is the utilization of exosomes (Exo), key secretions of MSCs. These exosomes not only carry the benefits inherent in MSCs but also exhibit unique physicochemical properties that make them effective drug carriers. Consequently, MSCs Exo is gaining recognition as a sophisticated drug delivery system, specifically designed for glioma treatment. The scope of MSCs Exo goes beyond being just an innovative drug delivery mechanism; it also shows potential as a standalone therapeutic option. This article aims to provide a detailed summary of the essential role of MSCs Exo in glioma progression and its growing importance as a drug delivery carrier in the fight against this formidable disease.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.