抗病毒药物:从 COVID-19 解读其意义

Rishabh Chalotra, Amanjot Singh, Shivani Chib, Swati Gautam, M. Amanat, Kakul Chaudhary, Manish Kumar, Randhir Singh
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引用次数: 0

摘要

病毒传播迅速,有可能在全球范围内引起大流行,造成重大人员伤亡,因此对人类健康构成严重威胁。抗病毒药物在减轻病毒感染的影响方面发挥着关键作用。然而,由于病毒固有的特性,如基因重组能力和快速进化,治疗病毒感染是一个多方面的过程。因此,目前抗病毒疗法的有效性可能会受到影响。本综述涵盖了病毒(重点是 COVID-19)影响人体的各种方式,并阐明了在制定有效的抗病毒疗法时所遇到的挑战。此外,还强调了传统抗病毒疗法的局限性。此外,还全面介绍了 41 种抗病毒药物,详细说明了这些药物的作用机制和给药途径。随后,还讨论了 9 种专门用于治疗 COVID-19 的药物,说明了这些药物的主要用途以及伴随的副作用。总之,尽管抗病毒药物在抗击病毒感染的斗争中仍然举足轻重,但与它们的开发和使用相关的障碍值得仔细考虑。为了设计出更有效、毒性更低的抗病毒干预措施来对抗 COVID-19 感染,持续的研究势在必行。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antiviral Medications: Unravelling their Significance in Context to COVID-19
Viruses represent a significant health menace due to their rapid transmissibility and potential to cause worldwide pandemics, resulting in substantial loss of human life. Antiviral agents play a pivotal role in mitigating the impact of viral infections. Nonetheless, treating viral infections is a multifaceted process due to the inherent characteristics of viruses, such as their capacity to undergo mutations and rapid evolution. Consequently, the effectiveness of current antiviral therapies can be impeded. This review encompasses the diverse manners in which viruses, emphasizing COVID-19, affect the human body and elucidates the challenges encountered in formulating efficacious antiviral treatments. Moreover, the limitations of conventional antiviral therapies are underscored. Additionally, a comprehensive compendium of 41 antiviral drugs is presented, detailing their mechanisms of action and routes of administration. Subsequently, the discussion includes 9 drugs repurposed for treating COVID-19, delineating their primary use as well as any accompanying side effects. In conclusion, while antiviral drugs remain pivotal in the battle against viral infections, the obstacles associated with their development and usage warrant careful consideration. Ongoing research is imperative to devise more potent and less toxic antiviral interventions against COVID-19 infection.
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