{"title":"抗病毒药物:从 COVID-19 解读其意义","authors":"Rishabh Chalotra, Amanjot Singh, Shivani Chib, Swati Gautam, M. Amanat, Kakul Chaudhary, Manish Kumar, Randhir Singh","doi":"10.2174/0126667975280977231224175043","DOIUrl":null,"url":null,"abstract":"\n\nViruses represent a significant health menace due to their rapid transmissibility and\npotential to cause worldwide pandemics, resulting in substantial loss of human life. Antiviral agents\nplay a pivotal role in mitigating the impact of viral infections. Nonetheless, treating viral infections is\na multifaceted process due to the inherent characteristics of viruses, such as their capacity to undergo\nmutations and rapid evolution. Consequently, the effectiveness of current antiviral therapies can be\nimpeded. This review encompasses the diverse manners in which viruses, emphasizing COVID-19,\naffect the human body and elucidates the challenges encountered in formulating efficacious antiviral\ntreatments. Moreover, the limitations of conventional antiviral therapies are underscored.\nAdditionally, a comprehensive compendium of 41 antiviral drugs is presented, detailing their\nmechanisms of action and routes of administration. Subsequently, the discussion includes 9 drugs\nrepurposed for treating COVID-19, delineating their primary use as well as any accompanying side\neffects. In conclusion, while antiviral drugs remain pivotal in the battle against viral infections, the\nobstacles associated with their development and usage warrant careful consideration. Ongoing\nresearch is imperative to devise more potent and less toxic antiviral interventions against COVID-19\ninfection.\n","PeriodicalId":10815,"journal":{"name":"Coronaviruses","volume":"26 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antiviral Medications: Unravelling their Significance in Context to COVID-19\",\"authors\":\"Rishabh Chalotra, Amanjot Singh, Shivani Chib, Swati Gautam, M. Amanat, Kakul Chaudhary, Manish Kumar, Randhir Singh\",\"doi\":\"10.2174/0126667975280977231224175043\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n\\nViruses represent a significant health menace due to their rapid transmissibility and\\npotential to cause worldwide pandemics, resulting in substantial loss of human life. Antiviral agents\\nplay a pivotal role in mitigating the impact of viral infections. Nonetheless, treating viral infections is\\na multifaceted process due to the inherent characteristics of viruses, such as their capacity to undergo\\nmutations and rapid evolution. Consequently, the effectiveness of current antiviral therapies can be\\nimpeded. This review encompasses the diverse manners in which viruses, emphasizing COVID-19,\\naffect the human body and elucidates the challenges encountered in formulating efficacious antiviral\\ntreatments. Moreover, the limitations of conventional antiviral therapies are underscored.\\nAdditionally, a comprehensive compendium of 41 antiviral drugs is presented, detailing their\\nmechanisms of action and routes of administration. Subsequently, the discussion includes 9 drugs\\nrepurposed for treating COVID-19, delineating their primary use as well as any accompanying side\\neffects. In conclusion, while antiviral drugs remain pivotal in the battle against viral infections, the\\nobstacles associated with their development and usage warrant careful consideration. Ongoing\\nresearch is imperative to devise more potent and less toxic antiviral interventions against COVID-19\\ninfection.\\n\",\"PeriodicalId\":10815,\"journal\":{\"name\":\"Coronaviruses\",\"volume\":\"26 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Coronaviruses\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/0126667975280977231224175043\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Coronaviruses","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0126667975280977231224175043","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Antiviral Medications: Unravelling their Significance in Context to COVID-19
Viruses represent a significant health menace due to their rapid transmissibility and
potential to cause worldwide pandemics, resulting in substantial loss of human life. Antiviral agents
play a pivotal role in mitigating the impact of viral infections. Nonetheless, treating viral infections is
a multifaceted process due to the inherent characteristics of viruses, such as their capacity to undergo
mutations and rapid evolution. Consequently, the effectiveness of current antiviral therapies can be
impeded. This review encompasses the diverse manners in which viruses, emphasizing COVID-19,
affect the human body and elucidates the challenges encountered in formulating efficacious antiviral
treatments. Moreover, the limitations of conventional antiviral therapies are underscored.
Additionally, a comprehensive compendium of 41 antiviral drugs is presented, detailing their
mechanisms of action and routes of administration. Subsequently, the discussion includes 9 drugs
repurposed for treating COVID-19, delineating their primary use as well as any accompanying side
effects. In conclusion, while antiviral drugs remain pivotal in the battle against viral infections, the
obstacles associated with their development and usage warrant careful consideration. Ongoing
research is imperative to devise more potent and less toxic antiviral interventions against COVID-19
infection.