我们是否正在进入前抗生素时代:印度德里一家三级医院慢性中耳炎患者对抗生素耐药性的惊人趋势

Nitish Aggarwal, D. Sethi, Akshay Tamrakar, Ashwani Sethi
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引用次数: 0

摘要

背景:慢性中耳炎是一种持续至少 12 周或更长时间的中耳裂隙感染。由于营养不良、过度拥挤和卫生条件差等因素,慢性中耳炎在印度的发病率很高。由于保罗-埃利希(Paul Ehrlich)和亚历山大-弗莱明(Alexander Fleming)等伟人的努力,抗菌药物成为治疗这种疾病的一种有效且随时可用的方法:在这项研究中,我们重新评估了印度一家三级医院中 COM 细菌学特征的变化趋势以及对大多数现有抗生素的敏感性模式:研究发现,最常见的病原体是铜绿假单胞菌、金黄色葡萄球菌、奇异变形杆菌、普通变形杆菌、肠球菌、大肠埃希菌和摩根菌。对常用抗生素的敏感性呈下降趋势,而对 MRSA 的敏感性则出现了惊人的增长:本研究观察到的趋势表明,我们的医院迫切需要制定抗生素政策、合理使用抗生素并提高警惕。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Are we ushering into the pre-antibiotic era: alarming trends of antibiotic resistance in chronic otitis media in a tertiary care hospital in Delhi, India
Background: Chronic otitis media is an infection of the middle ear cleft for at least 12 weeks or more. It has a high prevalence rate in India pertaining to factors like malnutrition, overcrowding and poor hygiene. Thanks to greats like Paul Ehrlich and Alexander Fleming, Antimicrobials are a powerful and readily available form of treatment for this disease. Methods: In this study we re-evaluated the changing trends in bacteriological profile of COM and the antibiotic sensitivity pattern to most of the currently available antibiotics in a tertiary care hospital in India. Results: Most common pathogens found in our study were Pseudomonas aeruginosa, Staphylococcus aureus, Proteus mirabilis, Proteus vulgaris, Enterococcus, Escherichia coli and Morganella morganii. A declining pattern in the sensitivity towards commonly used antibiotics with an alarming increase in MRSA was observed. Conclusions: The trends observed in our study warrant an urgent need for antibiotic policies, judicious use of antibiotics and vigilance in our hospitals.
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