聚合物体系的低温结构研究。66.在添加了尿素的冷冻二甲基亚砜中形成聚乙烯醇冷凝胶,然后用水取代有机介质进行水合的性质和微观结构

IF 1.4 4区 化学 Q4 CHEMISTRY, PHYSICAL
D. A. Michurov, O. Yu. Kolosova, V. I. Lozinsky
{"title":"聚合物体系的低温结构研究。66.在添加了尿素的冷冻二甲基亚砜中形成聚乙烯醇冷凝胶,然后用水取代有机介质进行水合的性质和微观结构","authors":"D. A. Michurov,&nbsp;O. Yu. Kolosova,&nbsp;V. I. Lozinsky","doi":"10.1134/S1061933X23600665","DOIUrl":null,"url":null,"abstract":"<p>“Primary” poly(vinyl alcohol) (PVA) cryogels have been obtained by cryogenic processing (freezing at –21.6°C for 12 h followed by defrosting via heating to 20°C at a rate of 0.03°C/min) of a 100 g/L solution of PVA in dimethyl sulfoxide (DMSO) in the absence and presence of urea (2 or 4 mol/L), which exhibits kosmotropic properties in such a medium. Subsequent hydration of the cryogels by replacing DMSO with water causes a decrease in the volume and weight of the samples, as well as leads to a significant increase in the elasticity modulus of resulting “secondary” cryogels. The absolute magnitude of such effects depends both on the concentration of urea in an initial PVA solution and on the volume ratio between gel samples and an aqueous extractant during their hydration. Using optical microscopy, it has been found that the presence of urea in the initial DMSO polymer solution in a concentration close to the limit of its solubility in such a medium induces the formation of a gel matrix with a wide-pore morphology. Since high-modulus secondary PVA cryogels are of great interest as materials for biomedical applications, the possibility of their functioning as carriers of drug delivery systems has been assessed in the work. Ibuprofen sodium salt has been used as a model drug. The analysis of the release kinetics of this substance within the framework of the Weibull function has been employed to show that the dynamic hydrogen bonding of its carboxylate groups with the hydroxyl groups of PVA decelerates the release of the drug from the polymer carrier, i.e., prolongs the release process. At the same time, the rate of the process depends on the urea content in the initial polymer solution most likely due to microstructural differences between the polymer phases of the macropore walls in the cryogel matrix.</p>","PeriodicalId":521,"journal":{"name":"Colloid Journal","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Study of Cryostructuring of Polymer System. 66. Properties and Microstructure of Poly(vinyl alcohol) Cryogels Formed in Frozen Dimethyl Sulfoxide with Additives of Urea and Then Hydrated by Replacing Organic Medium with Water\",\"authors\":\"D. A. Michurov,&nbsp;O. Yu. Kolosova,&nbsp;V. I. Lozinsky\",\"doi\":\"10.1134/S1061933X23600665\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>“Primary” poly(vinyl alcohol) (PVA) cryogels have been obtained by cryogenic processing (freezing at –21.6°C for 12 h followed by defrosting via heating to 20°C at a rate of 0.03°C/min) of a 100 g/L solution of PVA in dimethyl sulfoxide (DMSO) in the absence and presence of urea (2 or 4 mol/L), which exhibits kosmotropic properties in such a medium. Subsequent hydration of the cryogels by replacing DMSO with water causes a decrease in the volume and weight of the samples, as well as leads to a significant increase in the elasticity modulus of resulting “secondary” cryogels. The absolute magnitude of such effects depends both on the concentration of urea in an initial PVA solution and on the volume ratio between gel samples and an aqueous extractant during their hydration. Using optical microscopy, it has been found that the presence of urea in the initial DMSO polymer solution in a concentration close to the limit of its solubility in such a medium induces the formation of a gel matrix with a wide-pore morphology. Since high-modulus secondary PVA cryogels are of great interest as materials for biomedical applications, the possibility of their functioning as carriers of drug delivery systems has been assessed in the work. Ibuprofen sodium salt has been used as a model drug. The analysis of the release kinetics of this substance within the framework of the Weibull function has been employed to show that the dynamic hydrogen bonding of its carboxylate groups with the hydroxyl groups of PVA decelerates the release of the drug from the polymer carrier, i.e., prolongs the release process. At the same time, the rate of the process depends on the urea content in the initial polymer solution most likely due to microstructural differences between the polymer phases of the macropore walls in the cryogel matrix.</p>\",\"PeriodicalId\":521,\"journal\":{\"name\":\"Colloid Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-01-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Colloid Journal\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1061933X23600665\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Colloid Journal","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1061933X23600665","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0

摘要

摘要 通过低温处理(在-21.6°C下冷冻12小时,然后以0.03°C/分钟的速度加热到20°C解冻)100 g/L的聚乙烯醇(PVA)在二甲基亚砜(DMSO)中的溶液,在尿素(2或4 mol/L)不存在和存在的情况下,获得了 "初级 "聚乙烯醇(PVA)冷凝胶,尿素在这种介质中表现出各向同性。随后用水代替二甲基亚砜对冷凝胶进行水合,会导致样品体积和重量的减少,并显著增加所产生的 "二次 "冷凝胶的弹性模量。这种效应的绝对值取决于初始 PVA 溶液中尿素的浓度以及凝胶样品与水萃取剂在水合过程中的体积比。通过光学显微镜观察发现,初始 DMSO 聚合物溶液中尿素的浓度接近其在这种介质中的溶解极限时,就会形成具有宽孔形态的凝胶基质。由于高模量二级 PVA 低温凝胶作为生物医学应用材料备受关注,因此在这项工作中对其作为药物输送系统载体的可能性进行了评估。布洛芬钠盐被用作模型药物。在 Weibull 函数的框架内对这种物质的释放动力学进行了分析,结果表明,其羧酸基团与 PVA 羟基的动态氢键结合会减缓药物从聚合物载体中的释放速度,即延长释放过程。同时,这一过程的速度取决于初始聚合物溶液中的尿素含量,这很可能是由于低温凝胶基质中大孔壁聚合物相之间的微观结构差异造成的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Study of Cryostructuring of Polymer System. 66. Properties and Microstructure of Poly(vinyl alcohol) Cryogels Formed in Frozen Dimethyl Sulfoxide with Additives of Urea and Then Hydrated by Replacing Organic Medium with Water

Study of Cryostructuring of Polymer System. 66. Properties and Microstructure of Poly(vinyl alcohol) Cryogels Formed in Frozen Dimethyl Sulfoxide with Additives of Urea and Then Hydrated by Replacing Organic Medium with Water

Study of Cryostructuring of Polymer System. 66. Properties and Microstructure of Poly(vinyl alcohol) Cryogels Formed in Frozen Dimethyl Sulfoxide with Additives of Urea and Then Hydrated by Replacing Organic Medium with Water

“Primary” poly(vinyl alcohol) (PVA) cryogels have been obtained by cryogenic processing (freezing at –21.6°C for 12 h followed by defrosting via heating to 20°C at a rate of 0.03°C/min) of a 100 g/L solution of PVA in dimethyl sulfoxide (DMSO) in the absence and presence of urea (2 or 4 mol/L), which exhibits kosmotropic properties in such a medium. Subsequent hydration of the cryogels by replacing DMSO with water causes a decrease in the volume and weight of the samples, as well as leads to a significant increase in the elasticity modulus of resulting “secondary” cryogels. The absolute magnitude of such effects depends both on the concentration of urea in an initial PVA solution and on the volume ratio between gel samples and an aqueous extractant during their hydration. Using optical microscopy, it has been found that the presence of urea in the initial DMSO polymer solution in a concentration close to the limit of its solubility in such a medium induces the formation of a gel matrix with a wide-pore morphology. Since high-modulus secondary PVA cryogels are of great interest as materials for biomedical applications, the possibility of their functioning as carriers of drug delivery systems has been assessed in the work. Ibuprofen sodium salt has been used as a model drug. The analysis of the release kinetics of this substance within the framework of the Weibull function has been employed to show that the dynamic hydrogen bonding of its carboxylate groups with the hydroxyl groups of PVA decelerates the release of the drug from the polymer carrier, i.e., prolongs the release process. At the same time, the rate of the process depends on the urea content in the initial polymer solution most likely due to microstructural differences between the polymer phases of the macropore walls in the cryogel matrix.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Colloid Journal
Colloid Journal 化学-物理化学
CiteScore
2.20
自引率
18.20%
发文量
36
审稿时长
6-12 weeks
期刊介绍: Colloid Journal (Kolloidnyi Zhurnal) is the only journal in Russia that publishes the results of research in the area of chemical science dealing with the disperse state of matter and surface phenomena in disperse systems. The journal covers experimental and theoretical works on a great variety of colloid and surface phenomena: the structure and properties of interfaces; adsorption phenomena and structure of adsorption layers of surfactants; capillary phenomena; wetting films; wetting and spreading; and detergency. The formation of colloid systems, their molecular-kinetic and optical properties, surface forces, interaction of colloidal particles, stabilization, and criteria of stability loss of different disperse systems (lyosols and aerosols, suspensions, emulsions, foams, and micellar systems) are also topics of the journal. Colloid Journal also includes the phenomena of electro- and diffusiophoresis, electro- and thermoosmosis, and capillary and reverse osmosis, i.e., phenomena dealing with the existence of diffusion layers of molecules and ions in the vicinity of the interface.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信