越南一家教学医院下呼吸道感染患者中分离出的常见革兰氏阴性微生物的抗菌药耐药性模式

IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES
Hoang Huy Le, An Van Nguyen, Luong Huy Vu, Vinh Thi Ha Nguyen, Hoa Quynh Pham, Hung Van Le, Son Thai Nguyen, Hong Thu Le, Hung Viet Dinh, Nam Van Le, Tuan Dinh Le, Minh Nhat Le, Viet Hoang Nguyen, Kien Trung Hoang, Hai Ha Long Le
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引用次数: 0

摘要

这项横断面研究调查了从 4789 名住院下呼吸道感染(LRTI)患者体内分离出的革兰氏阴性病原体的抗菌药耐药性(AMR)模式。在采集的标本中,有 1,325 份(27.7%)标本的革兰氏阴性菌检测结果呈阳性。最常见的分离菌是鲍曼不动杆菌(38.6%)、铜绿假单胞菌(33.5%)、肺炎克雷伯菌(18.7%)、大肠埃希菌(5.6%)和产气克雷伯菌(3.5%)。抗菌药耐药性分析显示,鲍曼不动杆菌分离株的耐药率较高,除阿米卡星、三甲双胍/磺胺甲噁唑和可乐定外,对多种抗生素均有耐药性(79.9%-100%)。铜绿假单胞菌对可乐定的耐药性较低(10%),但对其他抗生素的耐药性较高。肺炎双球菌对大多数青霉素类抗生素的耐药率较高,从 90.0% 到 100.0%不等。相比之下,可乐定(7.1%)和阿米卡星(16.7%)的耐药率明显较低。产气荚膜杆菌对多种抗生素表现出高度耐药性,而对阿米卡星(95.1%)、氨苄西林(100.0%)和可乐定(100.0%)则表现出敏感性。大肠杆菌对氨苄西林(96.9%)有抗药性,但对几种抗生素的敏感性最高。该研究发现了抗菌药耐药性的显著趋势,并强调了多重耐药菌株的普遍性(产气荚膜钾杆菌的耐药率为 93.6%,其他分离菌株的耐药率为 69.1%-92.4%)。这些发现强调,迫切需要采取适当的抗生素管理措施,以消除与 LRTIs 相关的革兰氏阴性病原体的抗菌药耐药性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antimicrobial resistance patterns of common Gram-negative microorganisms isolated from patients with lower respiratory tract infection in a Teaching Hospital in Vietnam

This cross-sectional study investigated the antimicrobial resistance (AMR) patterns of Gram-negative pathogens isolated from 4,789 hospitalized patients with lower respiratory tract infections (LRTIs). Of the collected specimens, 1,325 (27.7%) specimens tested positive for Gram-negative bacteria. The most prevalent isolates were Acinetobacter baumannii (38.6%), Pseudomonas aeruginosa (33.5%), Klebsiella pneumoniae (18.7%), Escherichia coli (5.6%), and Klebsiella aerogenes (3.5%). Antimicrobial resistance analysis revealed high resistance rates among A. baumannii isolates, showing resistance (79.9%-100%) to multiple classes of antibiotics, except amikacin, trimethoprim/sulfamethoxazole, and colistin. P. aeruginosa displayed lower resistance to colistin (<10%), but resistance to other antibiotics was high. K. pneumoniae displayed elevated resistance rates against most penicillins, ranging from 90.0% to 100.0%. In contrast, the resistance rates were notably lower for colistin (7.1%) and amikacin (16.7%). K. aerogenes showed high resistance to various antibiotics, while sensitivity was observed for amikacin (95.1%), ampicillin (100.0%), and colistin (100.0%). E. coli exhibited resistance to ampicillin (96.9%) but showed maximum sensitivity to several antibiotics. The study identified significant antimicrobial resistance trends and highlighted the prevalence of multidrug-resistant strains (93.6% for K. aerogenes and 69.1%-92.4% for other isolates). These findings emphasize the urgent need for appropriate antibiotic stewardship practices to combat antimicrobial resistance in Gram-negative pathogens associated with LRTIs.

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来源期刊
CiteScore
4.50
自引率
4.50%
发文量
172
审稿时长
2 months
期刊介绍: Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.
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