{"title":"骨质疏松和骨质疏松症筛查检测:带校准因子和不带校准因子的钙骨定量超声与黄金标准双 X 射线吸收测定法的比较","authors":"Nutthapong Moonkum , Thanat Withayanuluck , Arun Somarungsan , Naphondej Sichai , Arisa Wongsiri , Witchayada Chawkhaodin , Podjana Ruengdach , Pasinee Boonsuk , Marut Pukdeeyorng , Gunjanaporn Tochaikul","doi":"10.1016/j.jocd.2024.101470","DOIUrl":null,"url":null,"abstract":"<div><p><em>Background</em>: osteoporosis is a worldwide major health problem that normally diagnosed in advanced stages. So, an early detection at preclinical stage is now an interesting issue. A key factor to early diagnosis the disease is the used of noninvasive bone densitometry. Dual energy x-ray absorptiometry (DXA) is the gold standard techniques for the proposed. However, the high cost, non-widely available and exposed to ionizing radiation are still a drawback of the machine. Therefore, a cheaper, smaller and non-ionizing device such quantitative ultrasound (QUS) is now a favor alternative method, but the possibility of used QUS measurement instead of DXA is still limited due to their uncertainties. So, the aim of our study was to calibrated the QUS with the DXA to allowing the possible to establish a calibration factor (CF) to improve the measured value closer to the standard method.</p><p><em>Methodology</em>: 135 healthy men and women aged 30–88 years were recruited for lumbar spine/femoral neck DXA and calcaneal QUS scanning. The Pearson's correlation between T- and Z-score from the two systems were studied. Moreover, the sensitivity, specificity and percentage of diagnosed accuracy for both with and without CF were calculated.</p><p><em>Results</em>: The significant correlation between the two systems showed a positive trajectory in highly correlation (<em>r</em> = 0.784–0.899). Analyses showed a higher sensitivity, specificity and reduced the misdiagnosed rates when applied the CF in QUS values.</p><p><em>Conclusions</em>: QUS results showed a significantly correlated with DXA results for both lumbar spine and femoral neck sites with some percentage differences. These differences can be reduced by applied an individual specific machine CF to improve a QUS results. As identification of high risk of osteopenia and osteoporosis to reduce the demand of DXA propose, using a QUS alternative method can be a reliable that provide a cheaper and lack of ionizing radiation.</p></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"27 2","pages":"Article 101470"},"PeriodicalIF":1.7000,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Osteopenia and Osteoporosis Screening Detection: Calcaneal Quantitative Ultrasound with and without Calibration Factor Comparison to Gold Standard Dual X-ray Absorptiometry\",\"authors\":\"Nutthapong Moonkum , Thanat Withayanuluck , Arun Somarungsan , Naphondej Sichai , Arisa Wongsiri , Witchayada Chawkhaodin , Podjana Ruengdach , Pasinee Boonsuk , Marut Pukdeeyorng , Gunjanaporn Tochaikul\",\"doi\":\"10.1016/j.jocd.2024.101470\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><em>Background</em>: osteoporosis is a worldwide major health problem that normally diagnosed in advanced stages. So, an early detection at preclinical stage is now an interesting issue. A key factor to early diagnosis the disease is the used of noninvasive bone densitometry. Dual energy x-ray absorptiometry (DXA) is the gold standard techniques for the proposed. However, the high cost, non-widely available and exposed to ionizing radiation are still a drawback of the machine. Therefore, a cheaper, smaller and non-ionizing device such quantitative ultrasound (QUS) is now a favor alternative method, but the possibility of used QUS measurement instead of DXA is still limited due to their uncertainties. So, the aim of our study was to calibrated the QUS with the DXA to allowing the possible to establish a calibration factor (CF) to improve the measured value closer to the standard method.</p><p><em>Methodology</em>: 135 healthy men and women aged 30–88 years were recruited for lumbar spine/femoral neck DXA and calcaneal QUS scanning. The Pearson's correlation between T- and Z-score from the two systems were studied. Moreover, the sensitivity, specificity and percentage of diagnosed accuracy for both with and without CF were calculated.</p><p><em>Results</em>: The significant correlation between the two systems showed a positive trajectory in highly correlation (<em>r</em> = 0.784–0.899). Analyses showed a higher sensitivity, specificity and reduced the misdiagnosed rates when applied the CF in QUS values.</p><p><em>Conclusions</em>: QUS results showed a significantly correlated with DXA results for both lumbar spine and femoral neck sites with some percentage differences. These differences can be reduced by applied an individual specific machine CF to improve a QUS results. As identification of high risk of osteopenia and osteoporosis to reduce the demand of DXA propose, using a QUS alternative method can be a reliable that provide a cheaper and lack of ionizing radiation.</p></div>\",\"PeriodicalId\":50240,\"journal\":{\"name\":\"Journal of Clinical Densitometry\",\"volume\":\"27 2\",\"pages\":\"Article 101470\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-01-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical Densitometry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1094695024000052\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Densitometry","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1094695024000052","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
摘要
背景骨质疏松症是一个世界性的重大健康问题,通常要到晚期才能确诊。因此,在临床前阶段进行早期检测是一个令人关注的问题。使用无创骨密度测量法是早期诊断该疾病的关键因素。双能 X 射线吸收测量法(DXA)是目前提出的金标准技术。然而,该仪器的缺点是成本高、不能广泛使用,而且会受到电离辐射。因此,定量超声波(QUS)这种更便宜、更小且无电离辐射的设备现在成为了一种受欢迎的替代方法,但由于其不确定性,用 QUS 测量代替 DXA 的可能性仍然有限。因此,我们研究的目的是将 QUS 与 DXA 进行校准,以便建立校准因子(CF),使测量值更接近标准方法。研究了两种系统的 T 值和 Z 值之间的皮尔逊相关性。结果两个系统之间的显著相关性显示出高度相关的正向轨迹(r=0.784-0.899)。分析表明,当在 QUS 值中应用 CF 时,灵敏度和特异性更高,误诊率也更低。这些差异可以通过应用特定的机器 CF 来减少,从而改善 QUS 结果。在识别骨质疏松和骨质疏松症的高风险以减少对 DXA 的需求方面,使用 QUS 替代方法是一种可靠的方法,不仅成本更低,而且没有电离辐射。
Osteopenia and Osteoporosis Screening Detection: Calcaneal Quantitative Ultrasound with and without Calibration Factor Comparison to Gold Standard Dual X-ray Absorptiometry
Background: osteoporosis is a worldwide major health problem that normally diagnosed in advanced stages. So, an early detection at preclinical stage is now an interesting issue. A key factor to early diagnosis the disease is the used of noninvasive bone densitometry. Dual energy x-ray absorptiometry (DXA) is the gold standard techniques for the proposed. However, the high cost, non-widely available and exposed to ionizing radiation are still a drawback of the machine. Therefore, a cheaper, smaller and non-ionizing device such quantitative ultrasound (QUS) is now a favor alternative method, but the possibility of used QUS measurement instead of DXA is still limited due to their uncertainties. So, the aim of our study was to calibrated the QUS with the DXA to allowing the possible to establish a calibration factor (CF) to improve the measured value closer to the standard method.
Methodology: 135 healthy men and women aged 30–88 years were recruited for lumbar spine/femoral neck DXA and calcaneal QUS scanning. The Pearson's correlation between T- and Z-score from the two systems were studied. Moreover, the sensitivity, specificity and percentage of diagnosed accuracy for both with and without CF were calculated.
Results: The significant correlation between the two systems showed a positive trajectory in highly correlation (r = 0.784–0.899). Analyses showed a higher sensitivity, specificity and reduced the misdiagnosed rates when applied the CF in QUS values.
Conclusions: QUS results showed a significantly correlated with DXA results for both lumbar spine and femoral neck sites with some percentage differences. These differences can be reduced by applied an individual specific machine CF to improve a QUS results. As identification of high risk of osteopenia and osteoporosis to reduce the demand of DXA propose, using a QUS alternative method can be a reliable that provide a cheaper and lack of ionizing radiation.
期刊介绍:
The Journal is committed to serving ISCD''s mission - the education of heterogenous physician specialties and technologists who are involved in the clinical assessment of skeletal health. The focus of JCD is bone mass measurement, including epidemiology of bone mass, how drugs and diseases alter bone mass, new techniques and quality assurance in bone mass imaging technologies, and bone mass health/economics.
Combining high quality research and review articles with sound, practice-oriented advice, JCD meets the diverse diagnostic and management needs of radiologists, endocrinologists, nephrologists, rheumatologists, gynecologists, family physicians, internists, and technologists whose patients require diagnostic clinical densitometry for therapeutic management.