食堂饮食会影响久坐和训练有素的雄性大鼠的骨骼微结构

IF 1.7 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM
Marcio Koiti Saito , Beatriz Kawano de Oliveira , Ana Paula Macedo , Caio Sorrentino dos Santos , Ricardo Tadeu Lopes , Jéssica Suzuki Yamanaka , Antonio Carlos Shimano
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引用次数: 0

摘要

导言不良的饮食习惯和久坐不动的生活方式会损害健康。有规律的体育锻炼能提高生活质量,对骨骼健康至关重要。因此,本研究旨在评估食堂饮食对久坐大鼠和运动大鼠骨质的影响:SD+CON,标准饮食和对照组;SD+SED,标准饮食和久坐组;SD+EX,标准饮食和运动组;CD+CON,食堂饮食和对照组;CD+SED,食堂饮食和久坐组;CD+EX,食堂饮食和运动组。运动方案包括每天 10 次爬梯训练,每周 5 天。每周对大鼠的体重和食物摄入量进行评估。10 周后,对动物实施安乐死,并收集白色脂肪组织。结果食堂饮食增加了脂肪组织(p<0.001),降低了骨矿物质密度(p=0.004),损害了生物力学特性(p<0.05)和组织形态学参数(p=0.044)。在这个实验模型中,结论是食堂饮食和久坐的生活方式会对骨骼产生负面影响,而爬梯运动并不能阻止不健康饮食的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cafeteria Diet Can Affect Bone Microarchitecture in Sedentary and Trained Male Rats

Introduction: Poor eating habits and a sedentary lifestyle can impair health. Regular physical activity improves the quality of life and is essential for bone health. Therefore, the present study aimed to evaluate the effects of the cafeteria diet on bone quality of sedentary and exercised rats.

Methods: Sixty young male Wistar rats were divided into six groups (n=10) according to diet composition and activity level, being: SD+CON, standard diet and control; SD+SED, standard diet and sedentary; SD+EX, standard diet and exercised; CD+CON, cafeteria diet and control; CD+SED, cafeteria diet and sedentary; CD+EX, cafeteria diet and exercised. The exercise protocol consisted of 10 ladder-climbing sessions/day, 5 days/week, and the sedentary rats were maintained in individual cages with limited mobility. Body mass and food intake were evaluated weekly. After 10 weeks, the animals were euthanized, and white adipose tissue was collected. The bone structure was evaluated by densitometry, mechanical tests, histomorphometric, and micro-computed tomography analyses.

Results: The cafeteria diet increased adipose tissue (p<0.001), decreased bone mineral density (p=0.004), and impaired biomechanical properties (p<0.05) and histomorphometry parameters (p=0.044). The sedentarism decreased bone mineral density (p<0.001) and biomechanical properties (p<0.05), and the exercise did not improve bone properties.

Conclusion: In this experimental model, it was concluded that the cafeteria diet and a sedentary lifestyle negatively affect bone, and ladder-climbing exercise could not prevent the effects of the unhealthy diet.

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来源期刊
Journal of Clinical Densitometry
Journal of Clinical Densitometry 医学-内分泌学与代谢
CiteScore
4.90
自引率
8.00%
发文量
92
审稿时长
90 days
期刊介绍: The Journal is committed to serving ISCD''s mission - the education of heterogenous physician specialties and technologists who are involved in the clinical assessment of skeletal health. The focus of JCD is bone mass measurement, including epidemiology of bone mass, how drugs and diseases alter bone mass, new techniques and quality assurance in bone mass imaging technologies, and bone mass health/economics. Combining high quality research and review articles with sound, practice-oriented advice, JCD meets the diverse diagnostic and management needs of radiologists, endocrinologists, nephrologists, rheumatologists, gynecologists, family physicians, internists, and technologists whose patients require diagnostic clinical densitometry for therapeutic management.
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