Harriet Cornwell, Nicola Toschi, Catherine Hamilton-Giachritsis, Marlene Staginnus, Areti Smaragdi, Karen Gonzalez-Madruga, Nuria Mackes, Jack Rogers, Anne Martinelli, Gregor Kohls, Nora Maria Raschle, Kerstin Konrad, Christina Stadler, Christine M Freitag, Stephane A De Brito, Graeme Fairchild
{"title":"利用基于表面的形态测量法确定年轻人抗逆境能力的皮层结构标志。","authors":"Harriet Cornwell, Nicola Toschi, Catherine Hamilton-Giachritsis, Marlene Staginnus, Areti Smaragdi, Karen Gonzalez-Madruga, Nuria Mackes, Jack Rogers, Anne Martinelli, Gregor Kohls, Nora Maria Raschle, Kerstin Konrad, Christina Stadler, Christine M Freitag, Stephane A De Brito, Graeme Fairchild","doi":"10.1093/scan/nsae006","DOIUrl":null,"url":null,"abstract":"<p><p>Previous research on the neurobiological bases of resilience in youth has largely used categorical definitions of resilience and voxel-based morphometry methods that assess gray matter volume. However, it is important to consider brain structure more broadly as different cortical properties have distinct developmental trajectories. To address these limitations, we used surface-based morphometry and data-driven, continuous resilience scores to examine associations between resilience and cortical structure. Structural MRI data from 286 youths (Mage = 13.6 years, 51% female) who took part in the European multi-site FemNAT-CD study were pre-processed and analyzed using surface-based morphometry. Continuous resilience scores were derived for each participant based on adversity exposure and levels of psychopathology using the residual regression method. Vertex-wise analyses assessed for correlations between resilience scores and cortical thickness, surface area, gyrification and volume. Resilience scores were positively associated with right lateral occipital surface area and right superior frontal gyrification and negatively correlated with left inferior temporal surface area. Moreover, sex-by-resilience interactions were observed for gyrification in frontal and temporal regions. Our findings extend previous research by revealing that resilience is related to surface area and gyrification in frontal, occipital and temporal regions that are implicated in emotion regulation and face or object recognition.</p>","PeriodicalId":94208,"journal":{"name":"Social cognitive and affective neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10868125/pdf/","citationCount":"0","resultStr":"{\"title\":\"Identifying cortical structure markers of resilience to adversity in young people using surface-based morphometry.\",\"authors\":\"Harriet Cornwell, Nicola Toschi, Catherine Hamilton-Giachritsis, Marlene Staginnus, Areti Smaragdi, Karen Gonzalez-Madruga, Nuria Mackes, Jack Rogers, Anne Martinelli, Gregor Kohls, Nora Maria Raschle, Kerstin Konrad, Christina Stadler, Christine M Freitag, Stephane A De Brito, Graeme Fairchild\",\"doi\":\"10.1093/scan/nsae006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Previous research on the neurobiological bases of resilience in youth has largely used categorical definitions of resilience and voxel-based morphometry methods that assess gray matter volume. However, it is important to consider brain structure more broadly as different cortical properties have distinct developmental trajectories. To address these limitations, we used surface-based morphometry and data-driven, continuous resilience scores to examine associations between resilience and cortical structure. Structural MRI data from 286 youths (Mage = 13.6 years, 51% female) who took part in the European multi-site FemNAT-CD study were pre-processed and analyzed using surface-based morphometry. Continuous resilience scores were derived for each participant based on adversity exposure and levels of psychopathology using the residual regression method. Vertex-wise analyses assessed for correlations between resilience scores and cortical thickness, surface area, gyrification and volume. Resilience scores were positively associated with right lateral occipital surface area and right superior frontal gyrification and negatively correlated with left inferior temporal surface area. Moreover, sex-by-resilience interactions were observed for gyrification in frontal and temporal regions. Our findings extend previous research by revealing that resilience is related to surface area and gyrification in frontal, occipital and temporal regions that are implicated in emotion regulation and face or object recognition.</p>\",\"PeriodicalId\":94208,\"journal\":{\"name\":\"Social cognitive and affective neuroscience\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-02-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10868125/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Social cognitive and affective neuroscience\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/scan/nsae006\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Social cognitive and affective neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/scan/nsae006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Identifying cortical structure markers of resilience to adversity in young people using surface-based morphometry.
Previous research on the neurobiological bases of resilience in youth has largely used categorical definitions of resilience and voxel-based morphometry methods that assess gray matter volume. However, it is important to consider brain structure more broadly as different cortical properties have distinct developmental trajectories. To address these limitations, we used surface-based morphometry and data-driven, continuous resilience scores to examine associations between resilience and cortical structure. Structural MRI data from 286 youths (Mage = 13.6 years, 51% female) who took part in the European multi-site FemNAT-CD study were pre-processed and analyzed using surface-based morphometry. Continuous resilience scores were derived for each participant based on adversity exposure and levels of psychopathology using the residual regression method. Vertex-wise analyses assessed for correlations between resilience scores and cortical thickness, surface area, gyrification and volume. Resilience scores were positively associated with right lateral occipital surface area and right superior frontal gyrification and negatively correlated with left inferior temporal surface area. Moreover, sex-by-resilience interactions were observed for gyrification in frontal and temporal regions. Our findings extend previous research by revealing that resilience is related to surface area and gyrification in frontal, occipital and temporal regions that are implicated in emotion regulation and face or object recognition.