解开复杂的相互作用:从全面的角度理解药物诱发的疾病和致畸性。

Q3 Medicine
Kartikay Prakash, Shashank Tiwari
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引用次数: 0

摘要

先天性疾病,又称药物诱发疾病(DIDs),是一种公认但尚未得到充分研究的现象,可能导致持久的痛苦、入院治疗、药物干预、长期的药物依赖和健康并发症。在当代个性化医疗时代,处方者必须紧跟毒理学领域的动态发展。先天性疾病可能是医疗干预的结果,包括诊断程序、治疗干预或预防措施。需要考虑的关键因素包括患者的实际年龄、饮食习惯、遗传倾向、原有病症、宿主反应机制减弱以及药物耐受性。致畸性与接触致畸剂、环境影响和药物干预导致的先天畸形和疾病的发生率有关。本综述的主要目的是为个人提供与先天性疾病相关的潜在风险的全面知识,从而有助于预防不可预见的不良后果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unravelling the Complex Interplay: Understanding Drug-induced Diseases and Teratogenicity from a Comprehensive Perspective.

Iatrogenic diseases, also referred to as drug-induced diseases (DIDs), represent a recognized yet inadequately investigated phenomenon that may result in enduring afflictions, hospital admissions, pharmacological interventions, protracted pharmaceutical reliance, and health complications. In the contemporary era of personalized medicine, it is imperative for prescribers to remain abreast of the dynamic advancements in the field of toxicology. Iatrogenic disorders may manifest as a result of medical interventions, including diagnostic procedures, therapeutic interventions, or preventative measures. Key factors to be taken into consideration encompass the patient's chronological age, dietary patterns, genetic predisposition, pre-existing medical conditions, diminished host response mechanisms, and pharmacological tolerance. Teratogenicity pertains to the prevalence of congenital anomalies and disorders resulting from exposure to teratogenic agents, environmental influences, and pharmacological interventions. The primary objective of this review is to provide individuals with comprehensive knowledge regarding the potential risks associated with iatrogenic diseases, thereby facilitating the prevention of unforeseen adverse outcomes.

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来源期刊
Current Drug Research Reviews
Current Drug Research Reviews Medicine-Psychiatry and Mental Health
CiteScore
3.70
自引率
0.00%
发文量
38
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