用于抗血栓治疗的巯基嘧啶模板金纳米簇。

IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
Jianghong Dai, Jiaojiao Lei, Tianyan Zhang, Jingcan You, Dalian Qin, Ya Wu, Yong Liu and Youkun Zheng
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引用次数: 0

摘要

在此,我们首次报道了巯基嘧啶模板金纳米团簇(DAMP-AuNCs)可作为一种新型抗凝剂候选物用于抗血栓药物的设计。抗凝机制显示,DAMP-AuNCs 可通过与纤维蛋白原相互作用显著抑制血栓形成。卡拉胶诱导的小鼠尾部血栓模型实验表明,DAMP-AuNCs 在体内的抗血栓功效与肝素相当。更重要的是,这些超小型 AuNCs 具有极佳的血液相容性,只会引起微乎其微的出血副作用。我们的研究是开发具有高度生物安全性的新型抗血栓药物的一次成功尝试。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Mercaptopyrimidine-templated gold nanoclusters for antithrombotic therapy†

Mercaptopyrimidine-templated gold nanoclusters for antithrombotic therapy†

Mercaptopyrimidine-templated gold nanoclusters for antithrombotic therapy†

Here we report for the first time that mercaptopyrimidine-templated gold nanoclusters (DAMP-AuNCs) can be used as a novel anticoagulant candidate for the design of antithrombotic drugs. Anticoagulant mechanisms revealed that DAMP-AuNCs significantly inhibited thrombus formation by interacting with fibrinogen. Carrageenan-induced mice tail thrombosis model experiments showed that DAMP-AuNCs had antithrombotic efficacy comparable to heparin in vivo. More importantly, these ultrasmall AuNCs possess excellent blood compatibility and only induce negligible bleeding side effects. Our study is a successful attempt at developing novel antithrombotic agents with high biosafety.

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来源期刊
Journal of Materials Chemistry B
Journal of Materials Chemistry B MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
11.50
自引率
4.30%
发文量
866
期刊介绍: Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive: Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices
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