壬二酸在皮肤病学中的多种用途:作用机制、制剂和潜在的治疗应用。

IF 1.4 4区 医学 Q3 ALLERGY
Postepy Dermatologii I Alergologii Pub Date : 2023-12-01 Epub Date: 2024-01-08 DOI:10.5114/ada.2023.133955
Natalia Sauer, Małgorzata Oślizło, Marta Brzostek, Julianna Wolska, Katarzyna Lubaszka, Katarzyna Karłowicz-Bodalska
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引用次数: 0

摘要

壬二酸(AZA)是一种天然的饱和二羧酸,其局部应用在皮肤病学中有多种用途。壬二酸具有抗炎、抗氧化和抗痤疮丙酸杆菌的特性,目前被用于治疗各种类型的痤疮,如红斑痤疮和寻常痤疮。AZA 是酪氨酸酶、线粒体呼吸链酶和 DNA 合成的抑制剂,也是有害自由基的清除剂,能抑制中性粒细胞产生活性氧。有趣的是,AZA 还对各种癌细胞具有抗增殖和细胞毒性作用。迄今为止,AZA 主要用于抑制黑色素细胞,因此被广泛用于治疗黄褐斑和炎症后色素沉着等色素沉着疾病。市面上具有化妆品和药物地位的外用制剂含有 5%至 20% 的 AZA,以凝胶和乳霜的形式存在。使用脂质体技术可以更好地控制制剂的药代动力学和药效学。局部使用时,AZA 的耐受性良好,副作用仅限于一般轻微和短暂的局部皮肤刺激。重要的是,脂质体技术使药物能够渗透皮肤各层,同时保持活性成分的高度积累。迄今为止,治疗皮肤癌的主要障碍是皮肤吸收不良,因此需要多次用药才能维持长期的活性水平。在本综述中,我们将介绍 AZA 的作用机制和药代动力学。我们将总结其在皮肤病治疗中的应用及其在皮肤癌治疗中的潜力。我们将对市场上的制剂进行概述,同时考虑到所使用的技术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The multiple uses of azelaic acid in dermatology: mechanism of action, preparations, and potential therapeutic applications.

Azelaic acid (AZA) is a naturally occurring saturated dicarboxylic acid whose topical application has found multiple uses in dermatology. Its anti-inflammatory, antioxidant and antimicrobial properties against Propionibacterium acne are currently used in the treatment of various types of acne such as rosacea and acne vulgaris. AZA is an inhibitor of tyrosinase, mitochondrial respiratory chain enzymes and DNA synthesis, and is a scavenger of harmful free radicals and inhibits the production of reactive oxygen species by neutrophils. Interestingly, AZA also has anti-proliferative and cytotoxic effects on various cancer cells. To date, its inhibitory effect on melanocytes has been mainly used, making it widely used in the treatment of hyperpigmentation disorders such as melasma and post-inflammatory hyperpigmentation. Commercially available topical formulations with cosmetic and drug status contain 5% to 20% AZA in the form of gels and creams. The use of liposomal technology allows greater control over the pharmacokinetics and pharmacodynamics of the formulations. When applied topically, AZA is well tolerated, and side effects are limited to generally mild and transient local skin irritation. Importantly, liposomal technology has enabled the drug to penetrate all layers of the skin while maintaining a very high accumulation of the active ingredient. This solution could be revolutionary for the treatment of skin cancer, where until now the main obstacle was poor absorption through the skin, making the treatment require multiple applications to maintain long-term activity levels. In this review, we will present the mechanism of action and pharmacokinetics of AZA. We will summarize its use in the treatment of dermatoses and its potential in skin cancer therapy. We will provide an overview of the preparations available on the market, taking into consideration technologies used.

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来源期刊
CiteScore
2.60
自引率
7.10%
发文量
107
审稿时长
6-12 weeks
期刊介绍: Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii is a bimonthly aimed at allergologists and dermatologists.
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