{"title":"基于多酚的局部给药纳米囊泡系统综述。","authors":"Anshu Singh, Zeeshan Fatima, Dipti Srivastava","doi":"10.2174/0115672018265118231213094410","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Polyphenols are naturally occurring compounds having more than one hydroxy functional group. They are ubiquitous secondary plant metabolites possessing a wide range of pharmacological activity. Brightly colored fruits and vegetables are the natural source of polyphenols. Majorly, they possess antioxidant, anti-inflammatory and antimicrobial properties which make them suitable candidates to target skin related disorders.</p><p><strong>Objective: </strong>This study is focused to explore the potential of polyphenols loaded nanovesicles for skin related disorders. The aim of the study is to review the applicability and efficacy of different vesicular systems encapsulated with various classes of polyphenols for skin related disorders, thus opening the opportunity for future studies based on these drug delivery systems.</p><p><strong>Method: </strong>Web of Science, PubMed, Scopus database, and the search engine Google Scholar were accessed for the literature search. The results were then filtered based on the titles, abstracts, and accessibility of the complete texts.</p><p><strong>Results: </strong>The expository evaluation of the literature revealed that various nanovesicles like liposomes, niosomes, ethosomes and transferosomes incorporating polyphenol have been formulated to address issues pertaining to delivery across the skin. These developed nano vesicular systems have shown improvement in the physicochemical properties and pharmacological action.</p><p><strong>Conclusion: </strong>Polyphenol based nano-vesicular formulations have proved to be an effective system for topical delivery and henceforth, they might curtail the use of other skin therapies having limited applicability.</p>","PeriodicalId":94287,"journal":{"name":"Current drug delivery","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Comprehensive Review on Polyphenols Based Nanovesicular System for Topical Delivery.\",\"authors\":\"Anshu Singh, Zeeshan Fatima, Dipti Srivastava\",\"doi\":\"10.2174/0115672018265118231213094410\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Polyphenols are naturally occurring compounds having more than one hydroxy functional group. They are ubiquitous secondary plant metabolites possessing a wide range of pharmacological activity. Brightly colored fruits and vegetables are the natural source of polyphenols. Majorly, they possess antioxidant, anti-inflammatory and antimicrobial properties which make them suitable candidates to target skin related disorders.</p><p><strong>Objective: </strong>This study is focused to explore the potential of polyphenols loaded nanovesicles for skin related disorders. The aim of the study is to review the applicability and efficacy of different vesicular systems encapsulated with various classes of polyphenols for skin related disorders, thus opening the opportunity for future studies based on these drug delivery systems.</p><p><strong>Method: </strong>Web of Science, PubMed, Scopus database, and the search engine Google Scholar were accessed for the literature search. The results were then filtered based on the titles, abstracts, and accessibility of the complete texts.</p><p><strong>Results: </strong>The expository evaluation of the literature revealed that various nanovesicles like liposomes, niosomes, ethosomes and transferosomes incorporating polyphenol have been formulated to address issues pertaining to delivery across the skin. These developed nano vesicular systems have shown improvement in the physicochemical properties and pharmacological action.</p><p><strong>Conclusion: </strong>Polyphenol based nano-vesicular formulations have proved to be an effective system for topical delivery and henceforth, they might curtail the use of other skin therapies having limited applicability.</p>\",\"PeriodicalId\":94287,\"journal\":{\"name\":\"Current drug delivery\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current drug delivery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/0115672018265118231213094410\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current drug delivery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0115672018265118231213094410","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
背景:多酚是具有一个以上羟基官能团的天然化合物。它们是无处不在的植物次生代谢物,具有广泛的药理活性。颜色鲜艳的水果和蔬菜是多酚的天然来源。它们主要具有抗氧化、抗炎和抗菌特性,因此适合用于治疗皮肤相关疾病:本研究的重点是探索多酚负载纳米颗粒治疗皮肤相关疾病的潜力。本研究的目的是回顾包裹了各种多酚的不同囊泡系统对皮肤相关疾病的适用性和疗效,从而为今后基于这些给药系统的研究提供机会:方法:使用 Web of Science、PubMed、Scopus 数据库和搜索引擎 Google Scholar 进行文献检索。方法:通过 Web Science、PubMus、Scopus 数据库和搜索引擎 Google Scholar 进行文献检索,然后根据标题、摘要和全文的可读性对结果进行筛选:对文献进行的阐述性评估显示,为了解决跨皮肤给药的相关问题,人们配制了各种纳米囊泡,如含有多酚的脂质体、niosomes、ethosomes 和 transferosomes。这些开发的纳米囊泡系统在理化性质和药理作用方面都有所改进:结论:以多酚为基础的纳米囊泡配方已被证明是一种有效的局部给药系统,因此可能会减少其他适用性有限的皮肤疗法的使用。
A Comprehensive Review on Polyphenols Based Nanovesicular System for Topical Delivery.
Background: Polyphenols are naturally occurring compounds having more than one hydroxy functional group. They are ubiquitous secondary plant metabolites possessing a wide range of pharmacological activity. Brightly colored fruits and vegetables are the natural source of polyphenols. Majorly, they possess antioxidant, anti-inflammatory and antimicrobial properties which make them suitable candidates to target skin related disorders.
Objective: This study is focused to explore the potential of polyphenols loaded nanovesicles for skin related disorders. The aim of the study is to review the applicability and efficacy of different vesicular systems encapsulated with various classes of polyphenols for skin related disorders, thus opening the opportunity for future studies based on these drug delivery systems.
Method: Web of Science, PubMed, Scopus database, and the search engine Google Scholar were accessed for the literature search. The results were then filtered based on the titles, abstracts, and accessibility of the complete texts.
Results: The expository evaluation of the literature revealed that various nanovesicles like liposomes, niosomes, ethosomes and transferosomes incorporating polyphenol have been formulated to address issues pertaining to delivery across the skin. These developed nano vesicular systems have shown improvement in the physicochemical properties and pharmacological action.
Conclusion: Polyphenol based nano-vesicular formulations have proved to be an effective system for topical delivery and henceforth, they might curtail the use of other skin therapies having limited applicability.