Friedländer reactions for novel annulated pyridotriazolothiazolopyridines: Synthetic approaches and antimicrobial evaluation

o-Aminoaldehyde 1 was employed as starting precursor for construction of some linear heterocyclic compounds. o-Aminoaldehyde 1 was permitted to undergo Friedländer reaction with some acyclic and cyclic methylene ketones giving the novel annulated heterocyclic systems 2-10. Moreover, the reactivity of o-aminoaldehyde 1 was examined toward some cyclic enamines and enols producing the corresponding annulated heterocyclic systems. The prepared compounds were investigated for their antimicrobial efficiency displaying different inhibition action toward the tested microorganisms. Based on analytical spectral and results, structures of the produced compounds were established.