中药对重症 COVID-19 患者治疗效果的影响:一项单中心研究

IF 4 2区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE
Yongjiu XIAO , Binbin LI , Chang LIU , Xiuyu HUANG , Ling MA , Zhirong QIAN , Xiaopeng ZHANG , Qian ZHANG , Dunqing LI , Xiaoqing CAI , Xiangyong YAN , Shuping LUO , Dawei XIANG , Kun XIAO
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引用次数: 0

摘要

在寻找有效治疗 COVID-19 的方法的过程中,重症监护病房(ICU)中重症患者的高死亡率带来了严峻的挑战。本研究探讨了传统中医药作为重症COVID-19辅助治疗的潜在益处。2020年2月至2020年4月期间,火神山医院重症监护室(ICU)共有110名COVID-19重症患者参与了这项观察性研究。所有患者均接受了标准的支持性治疗方案,其中81人还接受了中医药辅助治疗。我们对每位患者在治疗期间的临床特征和临床结果进行了密切监测和分析。我们的研究结果表明,中医组的死亡率明显低于非中医组(81 人中有 16 人死亡,29 人中有 24 人死亡;0.3 人/月,2.3 人/月)。在调整后的 Cox 比例危险模型中,中药治疗与生存几率的提高相关(P < 0.001)。此外,分析还显示,中药治疗可部分缓解炎症反应(表现为促炎细胞因子水平降低),并有助于多种机体功能的恢复,从而有可能提高 COVID-19 重症患者的存活率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of traditional Chinese medicine on treatment outcomes in severe COVID-19 patients: a single-centre study

As the search for effective treatments for COVID-19 continues, the high mortality rate among critically ill patients in Intensive Care Units (ICU) presents a profound challenge. This study explores the potential benefits of traditional Chinese medicine (TCM) as a supplementary treatment for severe COVID-19. A total of 110 critically ill COVID-19 patients at the Intensive Care Unit (ICU) of Vulcan Hill Hospital between Feb., 2020, and April, 2020 (Wuhan, China) participated in this observational study. All patients received standard supportive care protocols, with a subset of 81 also receiving TCM as an adjunct treatment. Clinical characteristics during the treatment period and the clinical outcome of each patient were closely monitored and analysed. Our findings indicated that the TCM group exhibited a significantly lower mortality rate compared with the non-TCM group (16 of 81 vs 24 of 29; 0.3 vs 2.3 person/month). In the adjusted Cox proportional hazards models, TCM treatment was associated with improved survival odds (P < 0.001). Furthermore, the analysis also revealed that TCM treatment could partially mitigate inflammatory responses, as evidenced by the reduced levels of proinflammatory cytokines, and contribute to the recovery of multiple organic functions, thereby potentially increasing the survival rate of critically ill COVID-19 patients.

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来源期刊
Chinese Journal of Natural Medicines
Chinese Journal of Natural Medicines INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY
CiteScore
7.50
自引率
4.30%
发文量
2235
期刊介绍: The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM). Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.
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