远程访谈评估重度抑郁症患者疾病严重程度的可行性:试点研究。

IF 2 Q3 NEUROSCIENCES
Neuropsychopharmacology Reports Pub Date : 2024-03-01 Epub Date: 2024-01-24 DOI:10.1002/npr2.12411
Tomiki Sumiyoshi, Yasunori Morio, Takahiro Kawashima, Hisateru Tachimori, Seiji Hongo, Taishiro Kishimoto, Koichiro Watanabe, Tempei Otsubo, Hideki Oi, Kazuyuki Nakagome, Jun Ishigooka
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引用次数: 0

摘要

目的:访谈质量是重度抑郁障碍(MDD)临床试验成功与否的重要因素。目前亟需建立一套可靠的远程临床评估访谈系统,以取代传统的面对面访谈:我们开展了一项多中心、随机、无盲、前瞻性、横断面研究,以评估对 MDD 患者进行远程访谈的可靠性(UMIN000041839)。符合条件的 MDD 患者在获得同意后的 28 天内接受了由不同评分者进行的蒙哥马利-奥斯伯格抑郁量表(MADRS)远程和面对面评估。患者被随机分为两组,一组首先接受面对面访谈评估,其次接受远程访谈评估(面对面优先组);另一组首先接受远程访谈评估,其次接受面对面访谈评估(远程优先组)。19名经过培训的人员(15名临床心理学家、3名护士和1名临床实验室技术人员)进行了访谈:在同时完成远程和面对面访谈的 59 名患者中(面对面优先组,32 人;远程优先组,27 人),51%(30 人)为女性;平均年龄为 41.6 岁(21-64 岁)。远程和亲临现场的 MADRS 分数之间有很强的关联性(r = 0.891,kappa = 0.901)。总体类内相关系数(ICC)为 0.886(95% 置信区间为 0.877-0.952),表明远程和面对面访谈中的 MADRS 分数具有良好的一致性。随着抑郁症严重程度的增加,ICC 有所下降:我们的研究结果表明,在评估 MDD 患者的症状严重程度时,远程访谈是一种可替代面对面访谈的可行方法,可促进日本的临床试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Feasibility of remote interviews in assessing disease severity in patients with major depressive disorder: A pilot study.

Aim: Interview quality is an important factor in the success of clinical trials for major depressive disorder (MDD). There is a substantial need to establish a reliable, remote clinical assessment interview system that can replace traditional in-person interviews.

Methods: We conducted a multicenter, randomized, unblinded, prospective, cross-sectional study to assess the reliability of remote interviews in patients with MDD (UMIN000041839). Eligible patients with MDD underwent remote and in-person sessions of the Montgomery-Åsberg Depression Rating Scale (MADRS) assessment performed by different raters within 28 days of providing consent. Patients were randomized to a group first assessed using in-person interviews and secondarily using remote interviews (in-person-first group) or a group first assessed by remote interviews and secondarily using in-person interviews (remote-first group). Nineteen trained people (15 clinical psychologists, 3 nurses, and 1 clinical laboratory technologist) performed interviews.

Results: Of 59 patients (in-person-first group, n = 32; remote-first group, n = 27) who completed both remote and in-person interviews, 51% (n = 30) were women; the mean age was 41.6 years (range, 21-64 years). There was a strong association between remote and in-person MADRS scores (r = 0.891, kappa = 0.901). An overall intraclass correlation coefficient (ICC) of 0.886 (95% confidence interval, 0.877-0.952) indicated good consistency between MADRS scores in remote and in-person interviews. The ICC decreased as the severity of depression increased.

Conclusion: Our results suggest remote interviews are a feasible alternative option to in-person interviews in assessing symptom severity in MDD patients and could promote clinical trials in Japan.

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来源期刊
Neuropsychopharmacology Reports
Neuropsychopharmacology Reports Psychology-Clinical Psychology
CiteScore
3.60
自引率
4.00%
发文量
75
审稿时长
14 weeks
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