Jing Yan, Jin Hou, Huihui Zhang, Xinyi Yang, Ying Sheng, Xiaoying Du, Demin Kong, Zhenghui Wang, Xiaoyong Ren, Liang Wu
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引用次数: 0
摘要
背景：特发性单侧声带麻痹（IUVFP）缺乏有效的治疗方法。我们在临床检查中发现，患者在接受喉神经刺激后，发音情况有所改善：本研究旨在探讨喉返神经（RLN）刺激对特发性单侧声带麻痹（IUVFP）患者发音的直接影响：62例经临床确诊的IUVFP患者接受了带针状电极的喉返神经刺激。进行喉镜检查、声学分析和嗓音感知评估，对干预前后的发声功能和嗓音质量进行定量比较：结果：喉镜图像显示，麻痹声带的活动范围更大（p p p p p 结论和意义：这项研究表明，RLN 刺激后，IUVFP 患者的发音得到了短期改善，这为试用受控 RLN 刺激和评估观察到的反应的持久性提供了概念证明。
Immediate effect of recurrent laryngeal nerve stimulation in patients with idiopathic unilateral vocal fold paralysis.
Background: There is a lack of effective treatment for idiopathic unilateral vocal fold paralysis (IUVFP). A better phonation was reported by patients after laryngeal nerve stimulation during our clinical examination.
Objectives: This study aims to investigate immediate effect of recurrent laryngeal nerve (RLN) stimulation on phonation in patients with IUVFP.
Material and methods: Sixty-two patients with clinically identified IUVFP underwent RLN stimulation with needle electrodes. Laryngoscopy, acoustic analysis, and voice perception assessment were performed for quantitative comparison of vocal function and voice quality before and after the intervention.
Results: Laryngoscopic images showed a larger motion range of the paralyzed vocal fold (p < .01) and better glottal closure (p < .01) after RLN stimulation. Acoustic analysis revealed that the dysphonia severity index increased significantly (p < .01) while the jitter and shimmer decreased after the intervention (p < .05). According to perceptual evaluation, RLN stimulation significantly increased RBH grades in patients with IUVFP (p < .01). Furthermore, the improvement in voice perception had a moderate positive correlation with the decrease in the glottal closure.
Conclusions and significance: This study shows a short-term improvement of phonation in IUVFP patients after RLN stimulation, which provides proof-of-concept for trialing a controlled delivery of RLN stimulation and assessing durability of any observed responses.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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