肺纤维化在原发性斯约恩病中并不常见:对 77 例患者计算机断层扫描特征的回顾性分析。

IF 4.9 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Grégoire Martin de Frémont , Alessandra Monaya , Guillaume Chassagnon , Samir Bouam , Emma Canniff , Pascal Cohen , Marion Casadevall , Luc Mouthon , Véronique Le Guern , Marie-Pierre Revel
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引用次数: 0

摘要

目的:本研究旨在描述符合2016年美国风湿病学会/欧洲抗风湿联盟(EULAR)原发性斯约格伦病(ppSD)分类标准的患者在计算机断层扫描(CT)中观察到的肺部异常:回顾性评估了2009年1月至2020年12月期间在国家罕见系统性自身免疫疾病参考资料中心日间护理中心就诊的所有原发性斯琼氏综合征患者,这些患者至少有一次胸部CT检查可供复查,并且可以计算累积EULAR斯琼氏综合征疾病活动指数(cumESSDAI)。对CT检查结果、临床症状和肺功能结果进行了复查:共纳入 77 名患者(73 名女性,4 名男性),诊断为 pSD 时的中位年龄为 51 岁(年龄范围:17-79 岁),中位随访时间为 6 年,中位 cumESSDAI 为 7。66名患者(86%)有抗SSA抗体。33名患者(33/77;43%)有呼吸道症状,肺功能检查无明显变化。40名患者(40/77;52%)的肺部CT结果异常,其中近一半患者没有呼吸道症状。抗-SSA 阳性和有淋巴瘤病史的患者更常出现胸部 CT 异常。气囊(28/77;36%)和镶嵌灌注(35/77;35%)是主要的异常现象,而在五名患者中观察到肺纤维化(5/77;6%):结论:半数以上的 pSD 患者 CT 检查结果异常,主要是气囊和镶嵌灌注,表明存在小气道疾病,而肺纤维化很少见,只有不到 10% 的此类患者观察到肺纤维化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lung fibrosis is uncommon in primary Sjögren's disease: A retrospective analysis of computed tomography features in 77 patients

Purpose

The purpose of this study was to describe lung abnormalities observed on computed tomography (CT) in patients meeting the 2016 American College of Rheumatology/European League Against Rheumatism (EULAR) classification criteria for primary Sjögren's disease (pSD).

Materials and methods

All patients with pSD seen between January 2009 and December 2020 in the day care centre of our National Reference Center for rare systemic autoimmune diseases, who had at least one chest CT examination available for review and for whom the cumulative EULAR Sjögren's Syndrome Disease Activity Index (cumESSDAI) could be calculated were retrospectively evaluated. CT examinations were reviewed, together with clinical symptoms and pulmonary functional results.

Results

Seventy-seven patients (73 women, four men) with a median age of 51 years at pSD diagnosis (age range: 17–79 years), a median follow-up time of 6 years and a median cumESSDAI of 7 were included. Sixty-six patients (86%) had anti-SSA antibodies. Thirty-three patients (33/77; 43%) had respiratory symptoms, without significant alteration in pulmonary function tests. Forty patients (40/77; 52%) had abnormal lung CT findings of whom almost half of them had no respiratory symptoms. Abnormalities on chest CT were more frequently observed in patients with anti-SSA positivity and a history of lymphoma. Air cysts (28/77; 36%) and mosaic perfusion (35/77; 35%) were the predominant abnormalities, whereas lung fibrosis was observed in five patients (5/77; 6%).

Conclusion

More than half of patients with pSD have abnormal CT findings, mainly air cysts and mosaic perfusion, indicative of small airways disease, whereas lung fibrosis is rare, observed in less than 10% of such patients.

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来源期刊
Diagnostic and Interventional Imaging
Diagnostic and Interventional Imaging Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
8.50
自引率
29.10%
发文量
126
审稿时长
11 days
期刊介绍: Diagnostic and Interventional Imaging accepts publications originating from any part of the world based only on their scientific merit. The Journal focuses on illustrated articles with great iconographic topics and aims at aiding sharpening clinical decision-making skills as well as following high research topics. All articles are published in English. Diagnostic and Interventional Imaging publishes editorials, technical notes, letters, original and review articles on abdominal, breast, cancer, cardiac, emergency, forensic medicine, head and neck, musculoskeletal, gastrointestinal, genitourinary, interventional, obstetric, pediatric, thoracic and vascular imaging, neuroradiology, nuclear medicine, as well as contrast material, computer developments, health policies and practice, and medical physics relevant to imaging.
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