韩国 Sysmex XN 系列细胞群数据参数的参考区间及其从成年早期到老年期的变化规律。

IF 2.2 4区 医学 Q3 HEMATOLOGY
Yong Jun Choi, Ju-Heon Park, Seon Cho, Hyeran Park, Suyoung Kim, Eunjoo Kwon, Han-Ik Cho, Eun-Hee Nah
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引用次数: 0

摘要

导言:细胞群数据(CPD)参数可能是筛查各种疾病(包括某些感染和骨髓增生异常综合征)的潜在生物标志物。本研究旨在确定韩国人群中细胞群数据参数的年龄和性别特异性参考区间(RIs):CPD 参数参考区间的参考人群包括 124 856 名 20-99 岁的受试者。CPD 参数来自韩国 13 个城市 17 个健康促进中心的 Sysmex XN-2000(日本神户)数据集。我们确定了年龄和性别的重要分区,并根据临床和实验室标准协会 C28-A3 指南计算了 RIs:结果:中性粒细胞区和淋巴细胞区的侧散射光强度不需要与性别相关的分区,50 岁以上者除外,其中女性的下限(LL)和上限(UL)较低。然而,淋巴细胞区的侧散射光分布宽度需要根据年龄和性别进行划分,其中女性的下限和上限较高。在中性粒细胞区域,男性的荧光分布宽度 LL 和 UL 较高,而在淋巴细胞区域,女性的荧光分布宽度 LL 和 UL 较高,但不需要与年龄相关的分区。男性中性粒细胞区、淋巴细胞区和单核细胞区的正向散射光强度不需要与年龄相关的分区:本研究为 CPD 参数确定了全面的年龄和性别特异性 RI,有助于证明这些参数在 Sysmex XN-2000 中的临床意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Reference intervals of cell population data parameters in Sysmex XN-Series and its patterns of changes from early adulthood to geriatric ages in South Korea

Reference intervals of cell population data parameters in Sysmex XN-Series and its patterns of changes from early adulthood to geriatric ages in South Korea

Introduction

Cell population data (CPD) parameters may be putative biomarkers for the screening of various diseases including some infections and myelodysplastic syndrome. This study aimed to establish the age- and sex-specific reference intervals (RIs) for the CPD parameters in the Korean population.

Methods

The reference population for the RIs of CPD parameters comprised 124 856 subjects aged 20–99 years. CPD parameters were obtained from Sysmex XN-2000 (Kobe, Japan) datasets from 17 health promotion centers in 13 South Korean cities. We determined significant partitions for age and sex, and calculated RIs according to Clinical and Laboratory Standards Institute C28-A3 guidelines.

Results

The side scattered light intensity in the neutrophil area and the lymphocyte area did not require sex-related partitioning except in those over the age of 50, among whom the lower limit (LL) and upper limit (UL) were lower in females. However, the side scattered light distribution width in the lymphocyte area required age- and sex-related partitioning, in which LL and UL were higher in females. The LL and UL of the fluorescent light distribution width were higher in males in the neutrophil area and higher in females in the lymphocyte area, but age-related partitioning was not required. The forward scattered light intensity in the neutrophil area, lymphocyte area, and monocyte area did not require age-related partitioning in males.

Conclusion

This study has determined comprehensive age- and sex-specific RIs for CPD parameters, which could help to prove the clinical significance of these parameters in the Sysmex XN-2000.

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来源期刊
CiteScore
4.50
自引率
6.70%
发文量
211
审稿时长
6-12 weeks
期刊介绍: The International Journal of Laboratory Hematology provides a forum for the communication of new developments, research topics and the practice of laboratory haematology. The journal publishes invited reviews, full length original articles, and correspondence. The International Journal of Laboratory Hematology is the official journal of the International Society for Laboratory Hematology, which addresses the following sub-disciplines: cellular analysis, flow cytometry, haemostasis and thrombosis, molecular diagnostics, haematology informatics, haemoglobinopathies, point of care testing, standards and guidelines. The journal was launched in 2006 as the successor to Clinical and Laboratory Hematology, which was first published in 1979. An active and positive editorial policy ensures that work of a high scientific standard is reported, in order to bridge the gap between practical and academic aspects of laboratory haematology.
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