不孕症、复发性流产和复发性体外受精失败中的男性遗传评估；临床方法。

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY

Urology Journal Pub Date : 2024-06-09 DOI:10.22037/uj.v20i.8044

Hamed Akhavizadegan

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引用次数: 0

摘要

目的：本综述从临床角度探讨了男性不育的遗传问题。与其他讨论不同类型遗传疾病（如 Klinefelter 和唐氏综合征）的相关综述不同，本综述侧重于这些遗传问题（如无精子症和少精子症）导致的临床特征：方法：使用与男性不育、复发性妊娠失败、复发性体外受精失败和遗传学相关的关键词，对 PubMed 上的临床文献进行了叙述性综述。检索包括 2020 年后在线发表的有英文评论的文章。根据现有文献确定标题，在对每篇稿件进行严格审查后，将临床事实归类到相应的标题下，并撰写初稿。结果：通过检索，共筛选出29篇相关文章。根据文献，临床上有针对无精子症、严重少精子症、严重畸形精子症、严重弱精子症、反复流产、反复体外受精失败的遗传学方法：结论：尽管已经发现了许多可影响男性生育能力和精子图谱的基因突变，但只有少数具有临床预测价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Male Genetic Evaluation in Infertility, Recurrent Abortion and Recurrent in Vitro Fertilization Failure; A Clinical Approach.

Purpose: This review presents a clinical approach to genetic issues in male infertility. Unlike other related reviews that discuss different types of genetic diseases (such as Klinefelter and Down syndrome), this review focuses on the clinical features that result from these genetic problems (such as azoospermia and oligospermia).

Methods: A narrative review of the clinical literature in PubMed was conducted using keywords related to male infertility, recurrent pregnancy loss, recurrent in vitro fertilization failure, and genetics. The search included articles with English reviews published online after 2020. Headlines were defined based on the available literature, and after a critical review of each manuscript, clinical facts were classified under the corresponding headlines, and a primary draft was written.

Results: 29 relevant articles were selected from the search. According to the literature, there are clinical genetic approaches for azoospermia, severe oligospermia, severe teratospermia, severe asthenospermia, recurrent miscarriage, and recurrent in vitro fertilization failure.

Conclusion: Although many mutations that can affect male fertility and spermogram have been identified, only a few have clinical predictive value.

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来源期刊

Urology Journal UROLOGY & NEPHROLOGY-

CiteScore

2.60

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： As the official journal of the Urology and Nephrology Research Center (UNRC) and the Iranian Urological Association (IUA), Urology Journal is a comprehensive digest of useful information on modern urology. Emphasis is on practical information that reflects the latest diagnostic and treatment techniques. Our objectives are to provide an exceptional source of current and clinically relevant research in the discipline of urology, to reflect the scientific work and progress of our colleagues, and to present the articles in a logical, timely, and concise format that meets the diverse needs of today’s urologist. Urology Journal publishes manuscripts on urology and kidney transplantation, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. Accordingly, original articles, case reports, and letters to editor are encouraged.