未提炼的糖对炎症的影响:干预研究的系统回顾

IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL
International Journal of Preventive Medicine Pub Date : 2023-10-30 eCollection Date: 2023-01-01 DOI:10.4103/ijpvm.ijpvm_318_22
Samarghand Ebadi, Azrina Azlan
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引用次数: 0

摘要

背景:未提炼的甘蔗产品中的植物化学物质、多酚和总抗氧化能力具有抗氧化活性,可减少炎症和氧化应激,这一点已得到公认。因此,我们进行了一项系统性综述,以评估食用未精制糖与炎症生物标志物之间的关系:截至 2021 年 12 月,我们在 Google Scholar、ScienceDirect、Scopus、Cochrane Library 和 ProQuest 数据库中检索了以炎症细胞因子、趋化因子和粘附分子为结果指标,报告未精制糖对炎症影响的研究。结果共评估了 36 项研究。在所有研究中,有五项研究(两项体外研究和三项动物研究)报告了未精制糖对细胞因子水平的影响,包括 IL-6、TNF-α、IL-10、IL-1β 和 IFN-γ。结论:根据体外和动物模型研究的结果,可以肯定包括琼脂在内的未提炼甘蔗产品可通过调节某些炎症途径对炎症产生保护作用,并对细胞因子的分泌产生有利影响。不过,由于研究结果还不够充分,因此强烈建议开展更多的科学研究,特别是精心设计的人体试验,以便得出有把握的结论。人体数据可能会鼓励工业界和公众在以糖为基础的食品中用未提炼的甘蔗取代纯糖,并为进一步的保健政策决策提供依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effect of Unrefined Sugar on Inflammation: A Systematic Review of Intervention Studies.

Background: It is well established that unrefined sugarcane products have antioxidant activity due to phytochemicals, polyphenols, and total antioxidant capacity, which may decrease inflammation and oxidative stress. Therefore, we conducted a systematic review to evaluate the association of unrefined sugar consumption with inflammatory biomarkers.

Methods: Google Scholar, ScienceDirect, Scopus, Cochrane Library, and ProQuest databases were searched up to December 2021 for studies that report the effect of unrefined sugar on inflammation according to inflammatory cytokines, chemokine, and adhesion molecules as outcome measures. Results: Thirty-six studies were evaluated. Across all research, five studies (two in vitro and three animal studies) reported the effect of unrefined sugar on levels of cytokines, including IL-6, TNF-α, IL-10, IL-1β, and IFN-γ. Additionally, the quality of the studies was assessed for risk of bias.

Conclusions: it is possible to affirm that unrefined sugarcane products, including jaggery, may have a protective effect on inflammation via regulating some of the inflammatory pathways and a favorable impact on cytokines secretion according to the results of in vitro and animal model studies. However, since the findings are still insufficient, more scientific research, especially well-designed human trials, is highly recommended to conclude the outcomes confidently. Human data may encourage industries and the public to replace purified sugar with unrefined sugarcane in sugar-based food and for further health-care policy decisions.

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来源期刊
International Journal of Preventive Medicine
International Journal of Preventive Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
4.80%
发文量
107
期刊介绍: International Journal of Preventive Medicine, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online journal with Continuous print on demand compilation of issues published. The journal’s full text is available online at http://www.ijpvmjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal will cover technical and clinical studies related to health, ethical and social issues in field of Preventive Medicine. Articles with clinical interest and implications will be given preference.
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