Yesmi P. Ahumada-Santos, Gabriela López-Angulo, Rebeca M. Pinto-González, Aldo F. Clemente-Soto, José A. López-Valenzuela, Francisco Delgado-Vargas
{"title":"棘皮果中可溶性黑色素的抗生物膜、细胞抗氧化、抗炎、免疫调节、细胞毒性和抗突变活性","authors":"Yesmi P. Ahumada-Santos, Gabriela López-Angulo, Rebeca M. Pinto-González, Aldo F. Clemente-Soto, José A. López-Valenzuela, Francisco Delgado-Vargas","doi":"10.1007/s13596-023-00735-w","DOIUrl":null,"url":null,"abstract":"<div><p>Melanins are widely distributed biopolymers that exhibit important biological activities. However, fruit melanins have been scarcely studied. In this work, the antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins (SMs) isolated from the <i>Randia echinocarpa</i> fruit (papache) were evaluated. The SMs inhibited biofilm formation in <i>Staphylococcus aureus</i> MDR and ATCC 43300 up to 60% at 1000 µg/mL; they presented a cellular antioxidant activity (60.02%) at 50 µg/mL, were immunomodulatory by increasing the peripheral blood mononuclear cells (PBMC) proliferation index (1.09 at 50 μg/mL), and inhibited HeLa cell proliferation by 77.39% (IC<sub>50</sub> = 9.34 µg/mL). SMs were neither toxic nor mutagenic in the <i>Salmonella</i> Typhimurium YG1024 strain and inhibited the 1-nitropyrene mutagenicity by 30.2%. The biological activities of papache SMs support their potential to be used in nutraceutical and pharmaceutical formulations.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 3","pages":"801 - 812"},"PeriodicalIF":1.8000,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins from Randia echinocarpa fruit\",\"authors\":\"Yesmi P. Ahumada-Santos, Gabriela López-Angulo, Rebeca M. Pinto-González, Aldo F. Clemente-Soto, José A. López-Valenzuela, Francisco Delgado-Vargas\",\"doi\":\"10.1007/s13596-023-00735-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Melanins are widely distributed biopolymers that exhibit important biological activities. However, fruit melanins have been scarcely studied. In this work, the antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins (SMs) isolated from the <i>Randia echinocarpa</i> fruit (papache) were evaluated. The SMs inhibited biofilm formation in <i>Staphylococcus aureus</i> MDR and ATCC 43300 up to 60% at 1000 µg/mL; they presented a cellular antioxidant activity (60.02%) at 50 µg/mL, were immunomodulatory by increasing the peripheral blood mononuclear cells (PBMC) proliferation index (1.09 at 50 μg/mL), and inhibited HeLa cell proliferation by 77.39% (IC<sub>50</sub> = 9.34 µg/mL). SMs were neither toxic nor mutagenic in the <i>Salmonella</i> Typhimurium YG1024 strain and inhibited the 1-nitropyrene mutagenicity by 30.2%. The biological activities of papache SMs support their potential to be used in nutraceutical and pharmaceutical formulations.</p></div>\",\"PeriodicalId\":7613,\"journal\":{\"name\":\"Advances in Traditional Medicine\",\"volume\":\"24 3\",\"pages\":\"801 - 812\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-01-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in Traditional Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s13596-023-00735-w\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Traditional Medicine","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1007/s13596-023-00735-w","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins from Randia echinocarpa fruit
Melanins are widely distributed biopolymers that exhibit important biological activities. However, fruit melanins have been scarcely studied. In this work, the antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins (SMs) isolated from the Randia echinocarpa fruit (papache) were evaluated. The SMs inhibited biofilm formation in Staphylococcus aureus MDR and ATCC 43300 up to 60% at 1000 µg/mL; they presented a cellular antioxidant activity (60.02%) at 50 µg/mL, were immunomodulatory by increasing the peripheral blood mononuclear cells (PBMC) proliferation index (1.09 at 50 μg/mL), and inhibited HeLa cell proliferation by 77.39% (IC50 = 9.34 µg/mL). SMs were neither toxic nor mutagenic in the Salmonella Typhimurium YG1024 strain and inhibited the 1-nitropyrene mutagenicity by 30.2%. The biological activities of papache SMs support their potential to be used in nutraceutical and pharmaceutical formulations.
期刊介绍:
Advances in Traditional Medicine (ADTM) is an international and peer-reviewed journal and publishes a variety of articles including original researches, reviews, short communications, and case-reports. ADTM aims to bridging the gap between Traditional knowledge and medical advances. The journal focuses on publishing valid, relevant, and rigorous experimental research and clinical applications of Traditidnal Medicine as well as medical classics. At the same time, the journal is devoted to communication among basic researcher and medical clinician interested in the advancement of Traditional Medicine. Topics covered by the journal are: Medical Classics & History; Biomedical Research; Pharmacology & Toxicology of Natural Products; Acupuncture & Moxibustion; Sasang Constitutional Medicine; Diagnostics and Instrumental Development; Clinical Research. ADTM is published four times yearly. The publication date of this journal is 30th March, June, September, and December.