颅内高压患者的光学相干断层血管造影分析。

IF 1.4 4区 医学 Q3 OPHTHALMOLOGY
European Journal of Ophthalmology Pub Date : 2024-09-01 Epub Date: 2024-01-23 DOI:10.1177/11206721241228349
Lidia Remolí-Sargues, Clara Monferrer-Adsuara, Belén López-Salvador, Carolina García-Villanueva, Alicia Gracia-García, Verónica Castro-Navarro, Enrique Cervera-Taulet
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引用次数: 0

摘要

导言:有关乳头水肿消退后颅内高压(IH)患者毛细血管周围微血管的证据仍然很少。本初步研究旨在确定 IIH 患者视神经和视网膜结构变化与毛细血管周围微血管之间的关联:我们进行了一项回顾性研究。研究包括 21 名 IIH 患者的 39 只眼睛。每位患者的 IIH 治疗情况和肥胖病史都进行了登记。此外,还进行了包括视网膜神经纤维层(RNFL)厚度和神经节细胞内丛状层(GCIPL)厚度在内的 OCT 分析,以及包括径向毛细血管周围丛的灌注密度(PD)和通量指数(FI)在内的 OCTA 分析:相关性分析表明,GCIPL 厚度与毛细血管周围灌注密度和通量指数之间的相关性较高(p r > 0.7),而 RNFL 厚度与毛细血管周围微血管参数之间的相关性较低(p r p 结论:毛细血管周围微血管测量值与 GCIPL 厚度之间的相关性较低,而 RNFL 厚度与毛细血管周围微血管参数之间的相关性较高:在 IIH 患者中,毛细血管周围测量值与 GCIPL 厚度高度相关。此外,与对照组相比,消退性乳头水肿患者的 GCIPL 厚度和毛细血管周径明显较低。因此,我们认为毛细血管周围微血管参数可能是 IIH 患者视神经萎缩的早期指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Optical coherence tomography angiography analysis in patients with intracranial hypertension.

Introduction: Evidence on peripapillary microvasculature in intracranial hypertension (IH) after the regression of papilledema is still scarce. The aim of this preliminary study was to determine the association between structural changes in the optic nerve and the retina and peripapillary microvasculature in patients with IIH.

Methods: We conducted a retrospective study. The study included 39 eyes of 21 patients with IIH. Treatment for IIH and history of obesity were registered from each patient. Moreover, OCT analysis including retinal nerve fiber layer (RNFL) thickness and ganglion cell-inner plexiform layer (GCIPL) thickness, and OCTA analysis including perfusion density (PD) and flux index (FI) of the radial peripapillary capillary plexus were performed.

Results: Correlation analysis revealed a high correlation between GCIPL thickness and peripapillary PD and FI (p < 0,05, r > 0,7), whereas the degree of correlation between RNFL thickness and peripapillary microvascular parameters was low (p < 0,05, r < 0,7). Patients with regressed papilledema had significantly lower GCIPL thickness and peripapillary PD than control subjects (p < 0,05).

Conclusion: Peripapillary microvascular measurements are highly correlated with GCIPL thickness in patients with IIH. Moreover, GCIPL thickness and peripapillary PD are significantly inferior in patients with regressed papilledema compared to control group. Thus, we suggested that peripapillary microvascular parameters may be an early indicator of optic nerve atrophy in patients with IIH.

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来源期刊
CiteScore
3.60
自引率
0.00%
发文量
372
审稿时长
3-8 weeks
期刊介绍: The European Journal of Ophthalmology was founded in 1991 and is issued in print bi-monthly. It publishes only peer-reviewed original research reporting clinical observations and laboratory investigations with clinical relevance focusing on new diagnostic and surgical techniques, instrument and therapy updates, results of clinical trials and research findings.
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