关于 "一种线粒体定位的双光子光敏剂产生碳自由基对抗缺氧肿瘤 "的通讯。

IF 16.1 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Angewandte Chemie International Edition Pub Date : 2024-10-07 Epub Date: 2024-01-23 DOI:10.1002/anie.202300176

Hans-Gert Korth

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引用次数: 0

摘要

研究表明，Chao 及其合作者在论文中提供的数据并不支持标题中所声称的活性 "碳自由基 "的形成。观察到的 ESR 光谱的分配和机理解释存在严重缺陷。因此，必须由其他反应性中间体来产生所观察到的肿瘤破坏效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Correspondence on "A Mitochondrion-Localized Two-Photon Photosensitizer Generating Carbon Radicals Against Hypoxic Tumors".

查看原文本刊更多论文

Correspondence on "A Mitochondrion-Localized Two-Photon Photosensitizer Generating Carbon Radicals Against Hypoxic Tumors".

It is shown that data presented in a paper by Chao and co-workers do not support the formation of active "Carbon Radicals" as claimed according to the title. The assignments of observed ESR spectra and the mechanistic interpretation are severely flawed. Hence, other reactive intermediates must be responsible for the observed tumor-damaging effects.

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来源期刊

Angewandte Chemie International Edition 化学-化学综合

CiteScore

26.60

自引率

6.60%

发文量

3549

审稿时长

1.5 months

期刊介绍： Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.