Survivin 在癌症中的作用概述：Survivin 在癌症中的作用：表达、调控、功能及其作为治疗靶点的潜力

IF 4.3 4区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Drug Targeting Pub Date : 2024-01-22 DOI:10.1080/1061186x.2024.2309563

Xian-long Fang, Xue-ping Cao, Jun Xiao, Yun Hu, Mian Chen, Hafiz Khuram Raza, Huai-yuan Wang, Xu He, Jin-fa Gu, Kang-jian Zhang

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引用次数: 0

摘要

Survivin 作为细胞凋亡抑制蛋白 (IAP) 家族的成员具有重要意义，因为它主要在肿瘤而非正常终末分化的成体中表达。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Overview of Role of Survivin in Cancer: Expression, Regulation, Functions, and its Potential as a Therapeutic Target

Survivin holds significant importance as a member of the inhibitor of apoptosis protein (IAP) family due to its predominant expression in tumors rather than normal terminally differentiated adult t...

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来源期刊

Journal of Drug Targeting 医学-药学

CiteScore

9.10

自引率

0.00%

发文量

165

审稿时长

2 months

期刊介绍： Journal of Drug Targeting publishes papers and reviews on all aspects of drug delivery and targeting for molecular and macromolecular drugs including the design and characterization of carrier systems (whether colloidal, protein or polymeric) for both vitro and/or in vivo applications of these drugs. Papers are not restricted to drugs delivered by way of a carrier, but also include studies on molecular and macromolecular drugs that are designed to target specific cellular or extra-cellular molecules. As such the journal publishes results on the activity, delivery and targeting of therapeutic peptides/proteins and nucleic acids including genes/plasmid DNA, gene silencing nucleic acids (e.g. small interfering (si)RNA, antisense oligonucleotides, ribozymes, DNAzymes), as well as aptamers, mononucleotides and monoclonal antibodies and their conjugates. The diagnostic application of targeting technologies as well as targeted delivery of diagnostic and imaging agents also fall within the scope of the journal. In addition, papers are sought on self-regulating systems, systems responsive to their environment and to external stimuli and those that can produce programmed, pulsed and otherwise complex delivery patterns.