Zhiqun Yu*, Chunhua Cao, Xuyang Zhao, Chenwei Gao, Lishan Geng, Minna Ren and Jiadi Zhou,
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Continuous Flow Synthesis of Crotonic Acid from Crotonaldehyde
At present, crotonic acid is mainly produced by oxidation of crotonaldehyde with O2 in batch reactors. This process suffers from poor selectivity, low yields, and safety hazards. An expeditious and highly efficient continuous-flow process has been developed for the production of crotonic acid from crotonaldehyde with air. Compared with the batch process, the continuous flow process has significant advantages such as higher yields and shorter residence time. The flow protocol in this work provided the desired product with over 91% yield and 99.5% purity. Moreover, the recovery of raw materials ensures high utilization of reagents. The process is safe, efficient, and low-cost, which has the potential for industrial production of crotonic acid.
期刊介绍：
The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.
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