EpiFloripa 老龄队列研究中维生素 D 血清浓度与抑郁症状的前瞻性关联：结构方程建模方法。

IF 3.6 3区医学 Q1 PSYCHIATRY

Revista Brasileira de Psiquiatria Pub Date : 2024-01-21 DOI:10.47626/1516-4446-2023-3153

Gilciane Ceolin, Júlia Dubois Moreira, Anna Quialheiro, Antônio Augusto Moura Silva, Eleonora d'Orsi, Débora Kurrle Rieger, Elisa Brietzke

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引用次数: 0

摘要

目的评估血清中[25（OH）D，25-羟基钙化醇]浓度对老年人抑郁症状的直接、间接和总体前瞻性影响：分析了EpiFloripa老年队列研究第二波（2013-2015年）和第三波（2017-2019年）的数据（≥60岁）。抑郁症状通过 15 项老年抑郁量表（GDS-15）进行评估。25（OH）D水平采用微粒子化学发光法测定。通过构建有向无环图（DAG）来确定最小调整集。结构方程建模（SEM）分析用于确定 25（OH）D 对抑郁症状的影响：共分析了 574 名老年人（63.1% 为女性）的数据。在随访中（人数=390），16.2%的老年人出现了严重抑郁症状（>或=6分）。SEM 分析显示，25（OH）D 对第 3 波的抑郁症状有微小的直接负效应（β=-0.11，P < 0.05），对第 3 波的抑郁症状有总体负效应（β=-0.13；P < 0.05）（25（OH）D 的增加导致抑郁症状的减少）。结论：研究结果表明，25（OH）D与抑郁症状之间存在前瞻性联系：研究结果表明，25（OH）D 与抑郁症状之间存在前瞻性联系，表明这对巴西南部的老年人具有长期影响。

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Vitamin D serum concentration is prospectively associated with depressive symptoms in the EpiFloripa Aging Cohort Study: a structural equation modeling approach.

Objective: To evaluate the direct, indirect, and total prospective effects of serum concentrations of [25(OH)D, 25-hydroxycolecalciferol] on depressive symptoms in older adults.

Methods: Data from the second (2013-2015) and third (2017-2019) waves of the EpiFloripa Aging Cohort Study (≥ 60 years) were analyzed. Depressive symptoms were assessed by the 15-item Geriatric Depression Scale (GDS-15). 25(OH)D levels were measured using the microparticle chemiluminescence method. A directed acyclic graph (DAG) was constructed to identify the minimum set of adjustments. Structural equation modeling (SEM) analysis was used to determine the effects of 25(OH)D on depressive symptoms.

Results: A total of 574 older adults' data were analyzed (63.1% female). In the follow-up (n=390), 16.2% of older adults presented high-severity of depressive symptoms (> or = 6 points). SEM analysis revealed a small direct and negative effect of 25(OH)D (β=-0.11, P < 0.05), and a total negative effect (β=-0.13; P < 0.05) on depressive symptoms on wave 3 (an increase of 25(OH)D led to a decrease on depressive symptoms). No direct effect on wave 2 and no indirect effect mediated by depressive symptoms in wave 2 were found.

Conclusions: Findings indicate a prospective association between 25(OH)D and depressive symptoms, suggesting a long-term effect in older adults from southern Brazil.

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来源期刊

Revista Brasileira de Psiquiatria 医学-精神病学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Revista Brasileira de Psiquiatria (RBP) is the official organ of the Associação Brasileira de Psiquiatria (ABP - Brazilian Association of Psychiatry). The Brazilian Journal of Psychiatry is a bimonthly publication that aims to publish original manuscripts in all areas of psychiatry, including public health, clinical epidemiology, basic science, and mental health problems. The journal is fully open access, and there are no article processing or publication fees. Articles must be written in English.