源自土壤的链霉菌 S045 的新型生物活性次生代谢物及其抗菌和抗 III 型分泌系统活性。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-07-03 DOI:10.1080/14786419.2024.2306601

Xiaochun Zhang , Yuliang Song , Zhiqiang Zhang , Chunhua Lu , Yuemao Shen

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引用次数: 0

摘要

从源自土壤的链霉菌 S045 菌株的 ISP3 琼脂培养物中分离出了七种化合物。根据一维、二维核磁共振光谱数据、HR ESI 质谱、X 射线衍射分析以及与已报道数据的比较，确定了这些化合物的结构。经鉴定，新化合物分别为(S)-4-(1-羟乙基)喹啉-2-甲酰胺（1）和 4-羟甲基-2-(4-甲基戊基)-4,5-二氢呋喃-3-甲酸甲酯（3）。对它们的抗菌和抗 III 型分泌系统（T3SS）活性进行了评估。

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New bioactive secondary metabolites from the soil-derived Streptomyces sp. S045 and their anti-bacterial and anti-type III secretion system activities

A total of seven compounds were isolated from the ISP3 agar cultures of a soil-derived Streptomyces sp. S045 strain. Their structures were determined based on 1D, 2D NMR spectroscopic data, HR ESI mass spectroscopy, X-ray diffraction analysis and comparison with the reported data. The new compounds were identified to be (S)-4-(1-hydroxyethyl)quinoline-2-carboxamide (1) and methyl 4-(hydroxymethyl)-2-(4-methylpentyl)-4,5-dihydrofuran-3-carboxylate (3), respectively. Their anti-bacterial and anti-type III secretion system (T3SS) activities were evaluated.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.