褪黑素对绝经后妇女血压、动脉僵化和生活质量的影响:随机对照试验。

IF 3.3 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE
Anne Kristine Amstrup, Lars Rejnmark
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引用次数: 0

摘要

目的研究表明,褪黑激素可促进心血管保护。以往的试验主要针对合并疾病的患者。在一项双盲安慰剂对照研究中,我们将 41 名绝经后妇女随机分组,每天服用 10 毫克褪黑素或安慰剂,为期 3 个月。结果测量试验结果为血压、脉搏波速度(PWV)和睡眠质量(由匹兹堡睡眠质量指数(PSQI)评估)的变化。平均年龄为 63 岁(55-75 岁不等)。治疗后,脉搏波速度的变化在各组之间没有差异:安慰剂 1.1% (IQR -2.1;9.9) vs. 褪黑激素 0.0% (IQR-9.8;4.1), p=0.43)。卧床血压(24 小时)无夜间变化:安慰剂组收缩压为-2.3%(IQR -9.6;11.5),褪黑素组收缩压为-1.9%(IQR-4.7;4.2),P=0.81。安慰剂组舒张压变化:-0.7% (IQR -13.2;6.6),褪黑素组舒张压变化:1.8% (IQR -13.2;6.6):1.8%(IQR -5.1;10.0),P=0.53。两组基线睡眠质量均较差(安慰剂组:PSQI 6.0(IQR -5.1;10.0结论 褪黑素的耐受性良好,但我们没有观察到心血管方面的改善。结论褪黑素的耐受性很好,但我们没有观察到对心血管的改善作用。对于总体健康状况良好的绝经后妇女,褪黑素对心血管的额外益处很少。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of melatonin on blood pressure, arterial stiffness and quality of life in postmenopausal women: A randomized controlled trial

Objectives

Studies suggest that melatonin may promote cardiovascular protection. Previous trials have primarily been performed on co-morbid patients. Little information exist on the effect in postmenopausal women with general good health.

Design, participants and intervention

In a double-blinded placebo-controlled study, we randomized 41 postmenopausal women to either 10 mg melatonin per day or placebo for 3 months.

Outcome measures

Outcomes of the trial was changes in blood pressure, pulse wave velocity (PWV), and quality of sleep evaluated by Pittsburgh Sleep Quality Index (PSQI).

Results

Thirty-nine women completed the study. Mean age was 63 years (range 55–75 years). Over the 3 months of the trial, PWV did not differ between groups: Placebo 1.1% (IQR −2.1;9.9) vs. melatonin 0.0% (IQR-9.8;4.1), p = 0.43). The were no significant differences in blood pressure bewteen melatonin and placebo group. Both groups had a pour quality of sleep at baseline (placebo: PSQI 6.0 (IQR 3.3; 8.8) vs. melatonin PSQI 6.0 (IQR 3.0; 10.0), p = 0.94), which did not change in response to treatment.

Conclusion

In healthy postmenopausal women, supplementation with 10 mg melatonin was well-tolerated, but we did not observe any significant improvements in pulse wave velocity, blood pressure or quality of sleep compared with placebo.

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来源期刊
Complementary therapies in medicine
Complementary therapies in medicine 医学-全科医学与补充医学
CiteScore
8.60
自引率
2.80%
发文量
101
审稿时长
112 days
期刊介绍: Complementary Therapies in Medicine is an international, peer-reviewed journal that has considerable appeal to anyone who seeks objective and critical information on complementary therapies or who wishes to deepen their understanding of these approaches. It will be of particular interest to healthcare practitioners including family practitioners, complementary therapists, nurses, and physiotherapists; to academics including social scientists and CAM researchers; to healthcare managers; and to patients. Complementary Therapies in Medicine aims to publish valid, relevant and rigorous research and serious discussion articles with the main purpose of improving healthcare.
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