SP-A 的免疫调节功能

IF 3.2 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular immunology Pub Date : 2024-01-19 DOI:10.1016/j.molimm.2024.01.005

Shu Dong , Hongyuan Pang , Fan Li , Mengqing Hua , Meng Liang , Chuanwang Song

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引用次数: 0

摘要

表面活性蛋白 A（SP-A）是一种天然免疫分子，在肺部健康中发挥着重要作用。SP-A 通过 C 型碳水化合物识别域识别并结合微生物表面糖基，然后通过胶原样区域结合相应的细胞表面受体（如 C1qRp、CRT-CD91 复合物、CD14、SP-R210、Toll 样受体、SIRP-α、CR3 等），继而介导生物效应。SP-A 通过促进肺泡 II 型上皮细胞吸收表面活性物质和肺泡巨噬细胞吞噬病原微生物来调节肺部先天性免疫。SP-A 还通过抑制 DC 成熟、T 细胞增殖和分化来调节肺适应性免疫。本文回顾了 SP-A 与适应性免疫和内在免疫之间的最新关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Immunoregulatory function of SP-A

Surfactant protein A (SP-A), a natural immune molecule, plays an important role in lung health. SP-A recognizes and binds microbial surface glycogroups through the C-type carbohydrate recognition domain, and then binds corresponding cell surface receptors (such as C1qRp, CRT-CD91 complex, CD14, SP-R210, Toll-like receptor, SIRP-α, CR3, etc.) through collagen-like region, and subsequently mediates biological effects. SP-A regulates lung innate immunity by promoting surfactant absorption by alveolar type II epithelial cells and phagocytosis of pathogenic microorganisms by alveolar macrophages. SP-A also regulates lung adaptive immunity by inhibiting DC maturation, and T cell proliferation and differentiation. This article reviews latest relationships between SP-A and adaptive and intrinsic immunity.

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来源期刊

Molecular immunology 医学-免疫学

CiteScore

6.90

自引率

2.80%

发文量

324

审稿时长

50 days

期刊介绍： Molecular Immunology publishes original articles, reviews and commentaries on all areas of immunology, with a particular focus on description of cellular, biochemical or genetic mechanisms underlying immunological phenomena. Studies on all model organisms, from invertebrates to humans, are suitable. Examples include, but are not restricted to: Infection, autoimmunity, transplantation, immunodeficiencies, inflammation and tumor immunology Mechanisms of induction, regulation and termination of innate and adaptive immunity Intercellular communication, cooperation and regulation Intracellular mechanisms of immunity (endocytosis, protein trafficking, pathogen recognition, antigen presentation, etc) Mechanisms of action of the cells and molecules of the immune system Structural analysis Development of the immune system Comparative immunology and evolution of the immune system "Omics" studies and bioinformatics Vaccines, biotechnology and therapeutic manipulation of the immune system (therapeutic antibodies, cytokines, cellular therapies, etc) Technical developments.