{"title":"利用二氟化碳合成正电子发射断层扫描中的 18F-radiotracers","authors":"Xiaohui Liu , Chunyang Huan , Xiaofeng Zhang , Wei Zhang","doi":"10.1016/j.jfluchem.2024.110253","DOIUrl":null,"url":null,"abstract":"<div><p>Positron emission tomography (PET) is a preclinical and clinical imaging technique that is extensively used in biomedical research and disease diagnosis to study and visualize biological and physiological processes. The positron emitter used most frequently for PET imaging is fluorine-18 (<sup>18</sup>F) due to its practical 109.8 min half-life, high yield production on fragile biomedical cyclotrons, and well-established <sup>18</sup>F-radiochemistry. Fluorine atom(s) presented in many drugs and biomarkers that provides the opportunity for the development radioligand-labeled with <sup>18</sup>F. Summarized in this paper are difluorocarbene (DFC)-enabled <sup>18</sup>F-radiosynthesis to introduce [<sup>18</sup>F]CF<sub>3</sub>, [<sup>18</sup>F]CF<sub>2</sub> and related motifs in organic molecules and to use them as bioactive radiotracers.</p></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"274 ","pages":"Article 110253"},"PeriodicalIF":1.7000,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Difluorocarbene-enabled synthesis of 18F-radiotracers in positron emission tomography\",\"authors\":\"Xiaohui Liu , Chunyang Huan , Xiaofeng Zhang , Wei Zhang\",\"doi\":\"10.1016/j.jfluchem.2024.110253\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Positron emission tomography (PET) is a preclinical and clinical imaging technique that is extensively used in biomedical research and disease diagnosis to study and visualize biological and physiological processes. The positron emitter used most frequently for PET imaging is fluorine-18 (<sup>18</sup>F) due to its practical 109.8 min half-life, high yield production on fragile biomedical cyclotrons, and well-established <sup>18</sup>F-radiochemistry. Fluorine atom(s) presented in many drugs and biomarkers that provides the opportunity for the development radioligand-labeled with <sup>18</sup>F. Summarized in this paper are difluorocarbene (DFC)-enabled <sup>18</sup>F-radiosynthesis to introduce [<sup>18</sup>F]CF<sub>3</sub>, [<sup>18</sup>F]CF<sub>2</sub> and related motifs in organic molecules and to use them as bioactive radiotracers.</p></div>\",\"PeriodicalId\":357,\"journal\":{\"name\":\"Journal of Fluorine Chemistry\",\"volume\":\"274 \",\"pages\":\"Article 110253\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-01-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Fluorine Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0022113924000149\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Fluorine Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022113924000149","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Difluorocarbene-enabled synthesis of 18F-radiotracers in positron emission tomography
Positron emission tomography (PET) is a preclinical and clinical imaging technique that is extensively used in biomedical research and disease diagnosis to study and visualize biological and physiological processes. The positron emitter used most frequently for PET imaging is fluorine-18 (18F) due to its practical 109.8 min half-life, high yield production on fragile biomedical cyclotrons, and well-established 18F-radiochemistry. Fluorine atom(s) presented in many drugs and biomarkers that provides the opportunity for the development radioligand-labeled with 18F. Summarized in this paper are difluorocarbene (DFC)-enabled 18F-radiosynthesis to introduce [18F]CF3, [18F]CF2 and related motifs in organic molecules and to use them as bioactive radiotracers.
期刊介绍：
The Journal of Fluorine Chemistry contains reviews, original papers and short communications. The journal covers all aspects of pure and applied research on the chemistry as well as on the applications of fluorine, and of compounds or materials where fluorine exercises significant effects. This can include all chemistry research areas (inorganic, organic, organometallic, macromolecular and physical chemistry) but also includes papers on biological/biochemical related aspects of Fluorine chemistry as well as medicinal, agrochemical and pharmacological research. The Journal of Fluorine Chemistry also publishes environmental and industrial papers dealing with aspects of Fluorine chemistry on energy and material sciences. Preparative and physico-chemical investigations as well as theoretical, structural and mechanistic aspects are covered. The Journal, however, does not accept work of purely routine nature.
For reviews and special issues on particular topics of fluorine chemistry or from selected symposia, please contact the Regional Editors for further details.
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