利用新抗原特异性 T 细胞进行精准癌症免疫疗法

IF 81.1 1区医学 Q1 ONCOLOGY

Nature Reviews Clinical Oncology Pub Date : 2024-01-19 DOI:10.1038/s41571-024-00860-8

Marco Donia, Inge Marie Svane

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引用次数: 0

摘要

有几种新型个性化疗法以新抗原为靶点。这些策略需要鉴定合适的疫苗新表位或新抗原特异性T细胞受体（TCR）克隆型。在此，我们将讨论最近发表的一篇报告，该报告描述了一种转录和表型相结合的特征--NeoTCRPBL，它能从外周血中微创鉴定罕见的新抗原特异性TCR，从而实现更有效的基于T细胞的癌症疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Harnessing neoantigen-specific T cells for precision cancer immunotherapy

Several novel personalized therapies focus on targeting neoantigens. Such strategies require the identification of suitable vaccine neoepitopes or neoantigen-specific T cell receptor (TCR) clonotypes. Herein, we discuss a recently published report that describes a combined transcriptional and phenotype signature, NeoTCRPBL, that enables the minimally invasive identification of rare neoantigen-specific TCRs from peripheral blood that might enable more-effective T cell-based therapies against cancer.

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来源期刊

Nature Reviews Clinical Oncology 医学-肿瘤学

CiteScore

99.40

自引率

0.40%

发文量

114

审稿时长

6-12 weeks

期刊介绍： Nature Reviews publishes clinical content authored by internationally renowned clinical academics and researchers, catering to readers in the medical sciences at postgraduate levels and beyond. Although targeted at practicing doctors, researchers, and academics within specific specialties, the aim is to ensure accessibility for readers across various medical disciplines. The journal features in-depth Reviews offering authoritative and current information, contextualizing topics within the history and development of a field. Perspectives, News & Views articles, and the Research Highlights section provide topical discussions, opinions, and filtered primary research from diverse medical journals.