Swathi Gujral , Marcia Burns , Kirk I Erickson , Dana Rofey , Jeremiah J Peiffer , Simon M. Laws , Belinda Brown
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The <em>BDNF</em> Val66Met polymorphism and <em>APOE</em> ε4 carrier status were explored as genetic moderators of exercise effects on mental health symptoms.</p></div><div><h3>Results</h3><p>The exercise intervention did not influence mental health symptoms. The <em>BDNF</em> Val66Met polymorphism did not moderate intervention effects on mental health symptoms. <em>APOE</em> ε4 carrier status moderated the effect of intervention group on perceived stress over 6 months, such that <em>APOE</em> ε4 carriers, but not non-carriers, in the high-intensity aerobic training group showed a decline in perceived stress over 6 months.</p></div><div><h3>Conclusions</h3><p><em>APOE</em> ε4 carrier status may modify the benefits of high-intensity exercise on perceived stress such that <em>APOE</em> ε4 carriers show a greater decline in stress as a result of exercise relative to non-<em>APOE</em> ε4 carriers.</p></div>","PeriodicalId":47673,"journal":{"name":"International Journal of Clinical and Health Psychology","volume":"24 1","pages":"Article 100443"},"PeriodicalIF":5.3000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1697260024000085/pdfft?md5=290bfd18516f048e0f31ed1fcc5d5468&pid=1-s2.0-S1697260024000085-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Dose-response effects of exercise on mental health in community-dwelling older adults: Exploration of genetic moderators\",\"authors\":\"Swathi Gujral , Marcia Burns , Kirk I Erickson , Dana Rofey , Jeremiah J Peiffer , Simon M. Laws , Belinda Brown\",\"doi\":\"10.1016/j.ijchp.2024.100443\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background/Objective</h3><p>(1) Examine the role of exercise intensity on mental health symptoms in a community-based sample of older adults. (2) Explore the moderating role of genetic variation in brain-derived neurotrophic factor (<em>BDNF</em>) and apolipoprotein E (<em>APOE</em>) on the effects of exercise on mental health symptoms.</p></div><div><h3>Method</h3><p>This study is a secondary analysis of a three-arm randomized controlled trial, comparing the effects of 6 months of high-intensity aerobic training vs. moderate-intensity aerobic training vs. a no-contact control group on mental health symptoms assessed using the Depression, Anxiety, and Stress Scale (DASS). The <em>BDNF</em> Val66Met polymorphism and <em>APOE</em> ε4 carrier status were explored as genetic moderators of exercise effects on mental health symptoms.</p></div><div><h3>Results</h3><p>The exercise intervention did not influence mental health symptoms. The <em>BDNF</em> Val66Met polymorphism did not moderate intervention effects on mental health symptoms. <em>APOE</em> ε4 carrier status moderated the effect of intervention group on perceived stress over 6 months, such that <em>APOE</em> ε4 carriers, but not non-carriers, in the high-intensity aerobic training group showed a decline in perceived stress over 6 months.</p></div><div><h3>Conclusions</h3><p><em>APOE</em> ε4 carrier status may modify the benefits of high-intensity exercise on perceived stress such that <em>APOE</em> ε4 carriers show a greater decline in stress as a result of exercise relative to non-<em>APOE</em> ε4 carriers.</p></div>\",\"PeriodicalId\":47673,\"journal\":{\"name\":\"International Journal of Clinical and Health Psychology\",\"volume\":\"24 1\",\"pages\":\"Article 100443\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1697260024000085/pdfft?md5=290bfd18516f048e0f31ed1fcc5d5468&pid=1-s2.0-S1697260024000085-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Clinical and Health Psychology\",\"FirstCategoryId\":\"102\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1697260024000085\",\"RegionNum\":1,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHOLOGY, CLINICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Clinical and Health Psychology","FirstCategoryId":"102","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1697260024000085","RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHOLOGY, CLINICAL","Score":null,"Total":0}
Dose-response effects of exercise on mental health in community-dwelling older adults: Exploration of genetic moderators
Background/Objective
(1) Examine the role of exercise intensity on mental health symptoms in a community-based sample of older adults. (2) Explore the moderating role of genetic variation in brain-derived neurotrophic factor (BDNF) and apolipoprotein E (APOE) on the effects of exercise on mental health symptoms.
Method
This study is a secondary analysis of a three-arm randomized controlled trial, comparing the effects of 6 months of high-intensity aerobic training vs. moderate-intensity aerobic training vs. a no-contact control group on mental health symptoms assessed using the Depression, Anxiety, and Stress Scale (DASS). The BDNF Val66Met polymorphism and APOE ε4 carrier status were explored as genetic moderators of exercise effects on mental health symptoms.
Results
The exercise intervention did not influence mental health symptoms. The BDNF Val66Met polymorphism did not moderate intervention effects on mental health symptoms. APOE ε4 carrier status moderated the effect of intervention group on perceived stress over 6 months, such that APOE ε4 carriers, but not non-carriers, in the high-intensity aerobic training group showed a decline in perceived stress over 6 months.
Conclusions
APOE ε4 carrier status may modify the benefits of high-intensity exercise on perceived stress such that APOE ε4 carriers show a greater decline in stress as a result of exercise relative to non-APOE ε4 carriers.
期刊介绍：
The International Journal of Clinical and Health Psychology is dedicated to publishing manuscripts with a strong emphasis on both basic and applied research, encompassing experimental, clinical, and theoretical contributions that advance the fields of Clinical and Health Psychology. With a focus on four core domains—clinical psychology and psychotherapy, psychopathology, health psychology, and clinical neurosciences—the IJCHP seeks to provide a comprehensive platform for scholarly discourse and innovation. The journal accepts Original Articles (empirical studies) and Review Articles. Manuscripts submitted to IJCHP should be original and not previously published or under consideration elsewhere. All signing authors must unanimously agree on the submitted version of the manuscript. By submitting their work, authors agree to transfer their copyrights to the Journal for the duration of the editorial process.
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