SARS-CoV-2 病毒的结构和生命周期。

3区生物学 Q2 Biochemistry, Genetics and Molecular Biology

Progress in molecular biology and translational science Pub Date : 2024-01-01 Epub Date: 2024-01-04 DOI:10.1016/bs.pmbts.2023.09.001

Sameer Saleem Tebha, Aimen Tameezuddin, Sanchit Bajpai, Asiya Kamber Zaidi

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引用次数: 0

摘要

本书简明扼要地概述了导致 COVID-19 大流行的 SARS-CoV-2 病毒。它探讨了基于形态和核酸组成的病毒分类（重点是 DNA 和 RNA 病毒）、SARS-CoV-2 的结构（包括结构蛋白和非结构蛋白的细节）以及病毒复制机制。然后，本章深入探讨了冠状病毒，特别是 SARS-CoV-2 的特征和多样性，强调了它与其他β-冠状病毒的相似之处。本章广泛讨论了复制和转录复合体、RNA 延长和封顶，以及辅助蛋白在病毒复制和调节宿主免疫反应中的作用。

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SARS-CoV-2-Virus structure and life cycle.

This book chapter presents a concise overview of SARS-CoV-2, the virus responsible for the COVID-19 pandemic. It explores viral classification based on morphology and nucleic acid composition with a focus on DNA and RNA viruses, the SARS-CoV-2 structure including the structural as well as nonstructural proteins in detail, and the viral replication mechanisms. The chapter then delves into the characteristics and diversity of coronaviruses, particularly SARS-CoV-2, highlighting its similarities with other beta-coronaviruses. The replication and transcription complex, RNA elongation, and capping, as well as the role of accessory proteins in viral replication and modulation of the host immune response is discussed extensively.

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来源期刊

Progress in molecular biology and translational science 生物-生化与分子生物学

CiteScore

6.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientiﬁc importance. If today you read an Article or Letter in　Nature　or a Research Article or Report in　Science　reporting ﬁndings of exceptional importance, you likely will ﬁnd comprehensive coverage of that research area in a future　PMBTS　volume.