心肌左心室定量易感性绘图的特征。

IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Andrew Tyler, Li Huang, Karl Kunze, Radhouene Neji, Ronald Mooiweer, Charlotte Rogers, Pier Giorgio Masci, Sébastien Roujol
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引用次数: 0

摘要

背景:在评估心脏疾病(包括心肌内出血)时,心肌定量易感性图谱(QSM)可能比传统的 T2* 成像对铁的特异性更好。然而,心脏 QSM 的精确性和可重复性尚未定性。本研究旨在描述健康志愿者队列中的这些关键指标,并展示该方法在患者中的可行性:方法:采集自由呼吸的呼吸导航多回波三维梯度回波(GRE)图像,使用 MEDI 工具箱重建 QSM 图。这项技术首先在一个包含已知浓度钆管的感性模型中进行了评估。然后在 10 名健康志愿者中对心肌 QSM 进行了活体表征,每个受试者扫描两次。计算了每个 AHA 心肌节段的 QSM 平均节段磁感应强度、精确度(一个节段内体素磁感应强度的标准偏差)和可重复性(重复扫描之间节段平均磁感应强度的绝对差值)。最后,在 10 名患者(包括 4 名出血性心梗患者)中展示了该方法的可行性:结果:模型实验表明,测量和预测的易感性偏移之间存在很强的线性关系(R2 > 0.99)。对健康志愿者队列进行的 AHA 节段分析表明,平均节段易感度为 0.00 ± 0.02 ppm,平均精确度为 0.05 ± 0.04 ppm,平均重复性为 0.02 ± 0.02 ppm。所有患者均成功进行了心脏 QSM。结论:结论:心脏 QSM 的精确性和可重复性在模型和活体实验中得到了成功验证。结论:在模型和活体实验中成功鉴定了心脏 QSM 的精确性和可重复性,并在患者身上成功证明了该技术的可行性。虽然挑战依然存在,但现在有必要对该技术进行进一步的临床评估:试验登记:本研究不涉及医疗干预。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Characterization of quantitative susceptibility mapping in the left ventricular myocardium.

Background: Myocardial quantitative susceptibility mapping (QSM) may offer better specificity to iron than conventional T2* imaging in the assessment of cardiac diseases, including intra-myocardial hemorrhage. However, the precision and repeatability of cardiac QSM have not yet been characterized. The aim of this study is to characterize these key metrics in a healthy volunteer cohort and show the feasibility of the method in patients.

Methods: Free breathing respiratory-navigated multi-echo 3D gradient echo images were acquired, from which QSM maps were reconstructed using the Morphology Enhanced Dipole Inversion toolbox. This technique was first evaluated in a susceptibility phantom containing tubes with known concentrations of gadolinium. In vivo characterization of myocardial QSM was then performed in a cohort of 10 healthy volunteers where each subject was scanned twice. Mean segment susceptibility, precision (standard deviation of voxel magnetic susceptibilities within one segment), and repeatability (absolute difference in segment mean susceptibility between repeats) of QSM were calculated for each American Heart Association (AHA) myocardial segment. Finally, the feasibility of the method was shown in 10 patients, including four with hemorrhagic infarcts.

Results: The phantom experiment showed a strong linear relationship between measured and predicted susceptibility shifts (R2 > 0.99). For the healthy volunteer cohort, AHA segment analysis showed the mean segment susceptibility was 0.00 ± 0.02 ppm, the mean precision was 0.05 ± 0.04 ppm, and the mean repeatability was 0.02 ± 0.02 ppm. Cardiac QSM was successfully performed in all patients. Focal iron deposits were successfully visualized in the patients with hemorrhagic myocardial infarctions.

Conclusion: The precision and repeatability of cardiac QSM were successfully characterized in phantom and in vivo experiments. The feasibility of the technique was also successfully demonstrated in patients. While challenges still remain, further clinical evaluation of the technique is now warranted.

Trial registration: This work does not report on a health care intervention.

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来源期刊
CiteScore
10.90
自引率
12.50%
发文量
61
审稿时长
6-12 weeks
期刊介绍: Journal of Cardiovascular Magnetic Resonance (JCMR) publishes high-quality articles on all aspects of basic, translational and clinical research on the design, development, manufacture, and evaluation of cardiovascular magnetic resonance (CMR) methods applied to the cardiovascular system. Topical areas include, but are not limited to: New applications of magnetic resonance to improve the diagnostic strategies, risk stratification, characterization and management of diseases affecting the cardiovascular system. New methods to enhance or accelerate image acquisition and data analysis. Results of multicenter, or larger single-center studies that provide insight into the utility of CMR. Basic biological perceptions derived by CMR methods.
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