植入前基因检测：一部关于开拓、技术挑战、创新和伦理考量的非凡历史

IF 2.7 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Reproduction and Development Pub Date : 2024-01-18 DOI:10.1002/mrd.23727

Keith E. Latham

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引用次数: 0

摘要

胚胎植入前基因检测（PGT）已成为辅助生殖技术的有力辅助工具。本文回顾了植入前基因检测的起源和历史，并介绍了分子检测和取样方法的进展、其功能及其在预防遗传疾病和提高妊娠结局方面的应用。此外，还考虑了提高准确性和基因组覆盖率的潜力，以及与 PGT 功能不断扩大有关的一些新出现的伦理和立法考虑因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Preimplantation genetic testing: A remarkable history of pioneering, technical challenges, innovations, and ethical considerations

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Preimplantation genetic testing: A remarkable history of pioneering, technical challenges, innovations, and ethical considerations

Preimplantation genetic testing (PGT) has emerged as a powerful companion to assisted reproduction technologies. The origins and history of PGT are reviewed here, along with descriptions of advances in molecular assays and sampling methods, their capabilities, and their applications in preventing genetic diseases and enhancing pregnancy outcomes. Additionally, the potential for increasing accuracy and genome coverage is considered, as well as some of the emerging ethical and legislative considerations related to the expanding capabilities of PGT.

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来源期刊

Molecular Reproduction and Development 生物-发育生物学

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Molecular Reproduction and Development takes an integrated, systems-biology approach to understand the dynamic continuum of cellular, reproductive, and developmental processes. This journal fosters dialogue among diverse disciplines through primary research communications and educational forums, with the philosophy that fundamental findings within the life sciences result from a convergence of disciplines. Increasingly, readers of the Journal need to be informed of diverse, yet integrated, topics impinging on their areas of interest. This requires an expansion in thinking towards non-traditional, interdisciplinary experimental design and data analysis.