紧张型头痛患者的大脑结构和功能异常:磁共振成像研究的系统回顾

IF 2.9 3区 医学 Q2 NEUROSCIENCES
Mohammadamin Parsaei, Morvarid Taebi, Alireza Arvin, Hossein Sanjari Moghaddam
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引用次数: 0

摘要

紧张型头痛(TTH)是最常见的头痛形式,但人们对其潜在机制仍缺乏足够的了解。本文试图全面回顾对 TTH 患者进行的结构性和功能性磁共振成像(MRI)研究,以获得对 TTH 病理生理学的宝贵见解,并探索加强治疗策略的新途径。我们进行了系统性检索,以确定研究 TTH 患者与无头痛对照组 (HFC) 之间大脑 MRI 差异的相关文章。我们选择了 14 项研究,共纳入了 312 名确诊的 TTH 患者。其中,八项研究采用了传统磁共振成像,一项采用了弥散张量成像,五项采用了各种功能磁共振成像模式。这些研究的一致发现表明,TTH 患者的白质高密度(WMH)明显增加。此外,研究还发现,被认为与疼痛感知不同层面有关的特定脑区,包括皮质区(扣带回前皮质和后皮质、前额叶皮质、岛叶前皮质和后皮质)、皮质下区(丘脑、尾状核、丘脑和副岛叶)和小脑,可能参与了TTH的发病机制。然而,TTH 与颅内异常或颅内总容积之间并无明显关联。总之,这些发现支持了关于中枢机制在 TTH 病理生理学中作用的假设,并提供了可能与这些机制有关的脑区。由于有关这些区域在 TTH 中确切作用的数据很少,因此应进一步开展临床前和临床研究,以增进我们对 TTH 的了解,并加强有针对性的治疗方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Brain structural and functional abnormalities in patients with tension-type headache: A systematic review of magnetic resonance imaging studies

Tension-type headache (TTH) stands as the most prevalent form of headache, yet an adequate understanding of its underlying mechanisms remains elusive. This article endeavors to comprehensively review structural and functional magnetic resonance imaging (MRI) studies investigating TTH patients, to gain valuable insights into the pathophysiology of TTH, and to explore new avenues for enhanced treatment strategies. We conducted a systematic search to identify relevant articles examining brain MRI disparities between TTH individuals and headache-free controls (HFC). Fourteen studies, encompassing 312 diagnosed TTH patients, were selected for inclusion. Among these, eight studies utilized conventional MRI, one employed diffusion tensor imaging, and five implemented various functional MRI modalities. Consistent findings across these studies revealed a notable increase in white matter hyperintensity (WMH) in TTH patients. Furthermore, the potential involvement of the specific brain areas recognized to be involved in different dimensions of pain perception including cortical regions (anterior and posterior cingulate cortex, prefrontal cortex, anterior and posterior insular cortex), subcortical regions (thalamus, caudate, putamen, and parahippocampus), cerebellum in TTH pathogenesis was identified. However, no significant association was established between TTH and intracranial abnormalities or total intracranial volume. In conclusion, these findings support the hypotheses regarding the role of central mechanisms in TTH pathophysiology and offer probable brain regions implicated in these mechanisms. Due to the scarce data on the precise role of these regions in the TTH, further preclinical and clinical investigations should be done to advance our knowledge and enhance targeted therapeutic options of TTH.

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来源期刊
Journal of Neuroscience Research
Journal of Neuroscience Research 医学-神经科学
CiteScore
9.50
自引率
2.40%
发文量
145
审稿时长
1 months
期刊介绍: The Journal of Neuroscience Research (JNR) publishes novel research results that will advance our understanding of the development, function and pathophysiology of the nervous system, using molecular, cellular, systems, and translational approaches. JNR covers both basic research and clinical aspects of neurology, neuropathology, psychiatry or psychology. The journal focuses on uncovering the intricacies of brain structure and function. Research published in JNR covers all species from invertebrates to humans, and the reports inform the readers about the function and organization of the nervous system, with emphasis on how disease modifies the function and organization.
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