生命早期抗菌药耐药性基因的纵向和横向微生物传播的作用：从母婴双亲中获得的启示

IF 5.9 2区生物学 Q1 MICROBIOLOGY

Current opinion in microbiology Pub Date : 2024-01-17 DOI:10.1016/j.mib.2023.102424

Manuel Bernabeu , Elena Cabello-Yeves , Eduard Flores , Anna Samarra , Joanna Kimberley Summers , Alberto Marina , M Carmen Collado

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引用次数: 0

摘要

生命早期是新陈代谢、认知和免疫系统发育的关键窗口期，它受到母体微生物群和婴儿肠道微生物群的影响。抗生素暴露、分娩方式和母乳喂养方式会调节肠道微生物组和抗生素耐药基因（ARGs）库。生命早期的垂直和水平微生物基因转移以及这些转移背后的机制正在被揭示。在这篇综述中，我们旨在概述目前关于抗生素耐药性通过垂直和水平传播在母婴双亲中转移的知识，并强调这一领域的主要差距和挑战。

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Role of vertical and horizontal microbial transmission of antimicrobial resistance genes in early life: insights from maternal-infant dyads

Early life represents a critical window for metabolic, cognitive and immune system development, which is influenced by the maternal microbiome as well as the infant gut microbiome. Antibiotic exposure, mode of delivery and breastfeeding practices modulate the gut microbiome and the reservoir of antibiotic resistance genes (ARGs). Vertical and horizontal microbial gene transfer during early life and the mechanisms behind these transfers are being uncovered. In this review, we aim to provide an overview of the current knowledge on the transfer of antibiotic resistance in the mother–infant dyad through vertical and horizontal transmission and to highlight the main gaps and challenges in this area.

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来源期刊

Current opinion in microbiology 生物-微生物学

CiteScore

10.00

自引率

0.00%

发文量

114

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Microbiology is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of microbiology. It consists of 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Host-microbe interactions: bacteria Cell regulation Environmental microbiology Host-microbe interactions: fungi/parasites/viruses Antimicrobials Microbial systems biology Growth and development: eukaryotes/prokaryotes