什么是系留元素？

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Current Opinion in Genetics & Development Pub Date : 2024-01-18 DOI:10.1016/j.gde.2023.102151

Xiao Li , Michael Levine

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引用次数: 0

摘要

高分辨率微C图谱在果蝇中发现了一类专门的调控DNA，称为 "系链元件"（TE）。这些 300-500 bp 的元件有助于特定的长程基因组关联或环路。含 POZ 的转录因子 GAF（GAGA 相关因子）有助于环的形成。系链-系链相互作用通过远端增强子加速 Hox 基因的激活，并通过启动子-启动子关联协调重复基因（旁系基因）的转录。在果蝇大脑中，一些TE参与超长距离的增强子-启动子和启动子-启动子相互作用（元环）。我们讨论了系-系特异性的基础，并推测脊椎动物基因组中也存在类似的元素。

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What are tethering elements?

High-resolution Micro-C maps identified a specialized class of regulatory DNAs termed ‘tethering elements’ (TEs) in Drosophila. These 300–500-bp elements facilitate specific long-range genomic associations or loops. The POZ-containing transcription factor GAF (GAGA-associated factor) contributes to loop formation. Tether–tether interactions accelerate Hox gene activation by distal enhancers, and coordinate transcription of duplicated genes (paralogs) through promoter–promoter associations. Some TEs engage in ultra-long-range enhancer–promoter and promoter–promoter interactions (meta-loops) in the Drosophila brain. We discuss the basis for tether–tether specificity and speculate on the occurrence of similar elements in vertebrate genomes.

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来源期刊

Current Opinion in Genetics & Development 生物-细胞生物学

CiteScore

7.90

自引率

0.00%

发文量

102

审稿时长

1 months

期刊介绍： Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)