全肩关节置换术灾难性失败后的严重金属中毒--病例报告。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2024-11-01 Epub Date: 2024-01-18 DOI:10.1007/s00256-024-04575-w
Feyikemi O Ogunfuwa, Steven Needell, Ryan W Simovitch
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引用次数: 0

摘要

金属病是骨科硬件植入引起的一种不常见但后果严重的并发症,其特点是金属颗粒沉积在假体周围软组织中。由于肩关节不是负重关节,不易受到机械磨损的影响,因此不易发生颗粒病和金属病等情况,因此与肩关节假体相关的金属病的发生率非常罕见。然而,如果聚乙烯组件因磨损、断裂或解离而失效,全肩关节置换术中就会出现金属对金属的异常相互作用。如果不及时处理,金属中毒会引发免疫介导的局部组织不良反应,最终导致关节破坏以及邻近软组织和肌肉坏死。在本病例报告中,我们使用了最先进的光子计数探测器 CT,并辅以后处理金属伪影减少算法,对一名接受解剖全肩关节置换术的患者进行了金属病诊断。这种先进的成像方法能有效辨别植入失败的源头,并识别严重金属病变的表现,包括骨溶解和假瘤形成。先进的成像方法可以准确描述金属病变的严重程度和范围,从而帮助指导手术规划,减轻与此病症相关的严重并发症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Severe metallosis following catastrophic failure of total shoulder arthroplasty - a case report.

Metallosis is an unusual but consequential complication arising from orthopedic hardware implantation, characterized by the deposition of metallic particles in the periprosthetic soft tissues. The incidence of metallosis associated with shoulder arthroplasties is exceptionally rare since the shoulder is not a weight-bearing joint, making it less susceptible to mechanical wear and, consequently, to conditions like particle disease and metallosis. Nevertheless, anomalous metal-on-metal interactions can develop in total shoulder arthroplasties if the polyethylene component fails due to wear, fracture, or dissociation. If left unaddressed, metallosis can incite an adverse immune-mediated local tissue response, culminating in joint destruction and adjacent soft tissues and muscle necrosis. In this case report, the diagnosis of metallosis was made in a patient with an anatomic total shoulder arthroplasty using a state-of-the-art photon counting detector CT supplemented by post-processing metal artifact reduction algorithms. This advanced imaging approach was effective in discerning the source of implant failure and in identifying manifestations of severe metallosis including osteolysis and pseudotumor formation. Advanced imaging methods can accurately characterize the severity and extent of metallosis, thereby helping guide surgical planning to mitigate serious complications associated with this condition.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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