{"title":"接受放射性碘治疗的小儿分化型甲状腺癌患者的吸收剂量系数。","authors":"Tae-Eun Kwon, Cari M Kitahara, Choonsik Lee","doi":"10.1088/1361-6498/ad1fdc","DOIUrl":null,"url":null,"abstract":"<p><p>The escalating incidence of differentiated thyroid cancer (DTC) in pediatric patients and the resultant growing use of radioactive iodine (RAI) reinforce the need to evaluate radiation exposure to normal tissues and radiation-induced health risks in pediatric patients undergoing RAI therapy. In the current study, we calculated absorbed dose coefficients (i.e. absorbed dose per unit activity administered, mGy MBq<sup>-1</sup>) specific for pediatric patients with localized DTC undergoing RAI therapy following total thyroidectomy for use in epidemiological studies. We first modified previously-published biokinetic models for adult thyroid cancer patients to achieve a reasonable agreement with iodine biokinetics observed in pediatric patients or design principles addressed in the International Commission on Radiological Protection (ICRP) reference age-specific biokinetic models. We then combined the biokinetic models in conjunction with<i>S</i>values derived from ICRP reference pediatric voxel phantoms. The absorbed dose coefficients for pediatric patients were overall greater than those for adults with a ratio (pediatric/adult) up to 11.6 and rapidly decreased with increasing age. The sensitivity analysis showed that the renal clearance rate and<i>S</i>values may have the greatest impact on the absorbed dose coefficients with the rank correlation coefficients ranging from -0.53 to -0.82 (negative correlations) and from 0.51 to 0.80 (positive correlations), respectively. The results of the current study may be utilized in clinical or epidemiological studies to estimate organ-specific radiation absorbed doses and radiation-associated health risks among pediatric thyroid cancer patients.</p>","PeriodicalId":50068,"journal":{"name":"Journal of Radiological Protection","volume":" ","pages":""},"PeriodicalIF":1.4000,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Absorbed dose coefficients for pediatric differentiated thyroid cancer patients undergoing radioiodine therapy.\",\"authors\":\"Tae-Eun Kwon, Cari M Kitahara, Choonsik Lee\",\"doi\":\"10.1088/1361-6498/ad1fdc\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The escalating incidence of differentiated thyroid cancer (DTC) in pediatric patients and the resultant growing use of radioactive iodine (RAI) reinforce the need to evaluate radiation exposure to normal tissues and radiation-induced health risks in pediatric patients undergoing RAI therapy. In the current study, we calculated absorbed dose coefficients (i.e. absorbed dose per unit activity administered, mGy MBq<sup>-1</sup>) specific for pediatric patients with localized DTC undergoing RAI therapy following total thyroidectomy for use in epidemiological studies. We first modified previously-published biokinetic models for adult thyroid cancer patients to achieve a reasonable agreement with iodine biokinetics observed in pediatric patients or design principles addressed in the International Commission on Radiological Protection (ICRP) reference age-specific biokinetic models. We then combined the biokinetic models in conjunction with<i>S</i>values derived from ICRP reference pediatric voxel phantoms. The absorbed dose coefficients for pediatric patients were overall greater than those for adults with a ratio (pediatric/adult) up to 11.6 and rapidly decreased with increasing age. The sensitivity analysis showed that the renal clearance rate and<i>S</i>values may have the greatest impact on the absorbed dose coefficients with the rank correlation coefficients ranging from -0.53 to -0.82 (negative correlations) and from 0.51 to 0.80 (positive correlations), respectively. The results of the current study may be utilized in clinical or epidemiological studies to estimate organ-specific radiation absorbed doses and radiation-associated health risks among pediatric thyroid cancer patients.</p>\",\"PeriodicalId\":50068,\"journal\":{\"name\":\"Journal of Radiological Protection\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-02-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Radiological Protection\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://doi.org/10.1088/1361-6498/ad1fdc\",\"RegionNum\":4,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Radiological Protection","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1088/1361-6498/ad1fdc","RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
随着儿科分化型甲状腺癌(DTC)发病率的上升以及放射性碘(RAI)使用量的不断增加,我们更有必要对接受 RAI 治疗的儿科患者正常组织所受的辐照和辐射诱发的健康风险进行评估。在目前的研究中,我们计算了在甲状腺全切除术后接受 RAI 治疗的局部分化型甲状腺癌儿科患者的吸收剂量系数(即单位放射性活度吸收剂量,mGy MBq-1),以用于流行病学研究。我们首先修改了以前发表的成人甲状腺癌患者的生物动力学模型,使之与在儿科患者中观察到的碘生物动力学或国际辐射防护委员会(ICRP)参考的特定年龄生物动力学模型的设计原则达到合理的一致。然后,我们将生物动力学模型与参考国际放射防护委员会儿科体素模型得出的 S 值结合起来。儿科患者的吸收剂量系数总体上大于成人,其比率(儿科/成人)高达 11.6,并随着年龄的增加而迅速降低。敏感性分析表明,肾清除率和 S 值对吸收剂量系数的影响最大,其等级相关系数分别为 -0.53 至 -0.82(负相关)和 0.51 至 0.80(正相关)。本研究的结果可用于临床或流行病学研究,以估算小儿甲状腺癌患者特定器官的辐射吸收剂量和辐射相关的健康风险。
Absorbed dose coefficients for pediatric differentiated thyroid cancer patients undergoing radioiodine therapy.
The escalating incidence of differentiated thyroid cancer (DTC) in pediatric patients and the resultant growing use of radioactive iodine (RAI) reinforce the need to evaluate radiation exposure to normal tissues and radiation-induced health risks in pediatric patients undergoing RAI therapy. In the current study, we calculated absorbed dose coefficients (i.e. absorbed dose per unit activity administered, mGy MBq-1) specific for pediatric patients with localized DTC undergoing RAI therapy following total thyroidectomy for use in epidemiological studies. We first modified previously-published biokinetic models for adult thyroid cancer patients to achieve a reasonable agreement with iodine biokinetics observed in pediatric patients or design principles addressed in the International Commission on Radiological Protection (ICRP) reference age-specific biokinetic models. We then combined the biokinetic models in conjunction withSvalues derived from ICRP reference pediatric voxel phantoms. The absorbed dose coefficients for pediatric patients were overall greater than those for adults with a ratio (pediatric/adult) up to 11.6 and rapidly decreased with increasing age. The sensitivity analysis showed that the renal clearance rate andSvalues may have the greatest impact on the absorbed dose coefficients with the rank correlation coefficients ranging from -0.53 to -0.82 (negative correlations) and from 0.51 to 0.80 (positive correlations), respectively. The results of the current study may be utilized in clinical or epidemiological studies to estimate organ-specific radiation absorbed doses and radiation-associated health risks among pediatric thyroid cancer patients.
期刊介绍:
Journal of Radiological Protection publishes articles on all aspects of radiological protection, including non-ionising as well as ionising radiations. Fields of interest range from research, development and theory to operational matters, education and training. The very wide spectrum of its topics includes: dosimetry, instrument development, specialized measuring techniques, epidemiology, biological effects (in vivo and in vitro) and risk and environmental impact assessments.
The journal encourages publication of data and code as well as results.