评估体内磁共振引导聚焦超声消融治疗的声热模拟。

IF 3 3区 医学 Q2 ONCOLOGY
International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-01-17 DOI:10.1080/02656736.2023.2301489
Nicholas Richards, Douglas Christensen, Joshua Hillyard, Michelle Kline, Sara Johnson, Henrik Odéen, Allison Payne
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引用次数: 0

摘要

目的:评估兔模型聚焦超声(FUS)的数值模拟,将模拟加热特性与体内治疗期间收集的磁共振温度成像(MRTI)数据进行比较:对兔子模型的股二头肌进行 FUS 声波治疗,并收集三维 MRTI 数据。实验确定了兔子肌肉的声学和热学特性。创建了兔子的数字模型,并分配了特定组织类型的属性。使用混合角频谱 (HAS) 方法和 k 波进行了 FUS 模拟。使用基于潘尼斯生物热方程的热求解器将模拟的功率沉积模式转换为温度图。评估了模拟技术之间压力的一致性以及模拟和实验加热之间温度的一致性。结果:结果:使用 HAS 方法得出的模拟峰值压力比 k-Wave 模拟峰值压力高出 1.6 ± 2.7%。HAS 和 k-Wave 计算出的峰值压力的位置和 FWHM 显示出良好的一致性。当模拟中的肌肉吸声值调整为测量衰减的 54% 左右时,模拟和实验空间平均温度曲线的平均均方根误差为 0.046 ± 0.019 °C/W。模拟和实验 COTM 之间的平均距离为 3.25 ± 1.37 毫米。模拟声波的横向 FWHM 小于活体声波。结论:上述结果表明,HAS 和 k 波模拟结果一致,FUS 模拟可准确预测软组织体内应用的焦点位置和加热情况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of acoustic-thermal simulations of in vivo magnetic resonance guided focused ultrasound ablative therapy.

Purpose: To evaluate numerical simulations of focused ultrasound (FUS) with a rabbit model, comparing simulated heating characteristics with magnetic resonance temperature imaging (MRTI) data collected during in vivo treatment.

Methods: A rabbit model was treated with FUS sonications in the biceps femoris with 3D MRTI collected. Acoustic and thermal properties of the rabbit muscle were determined experimentally. Numerical models of the rabbits were created, and tissue-type-specific properties were assigned. FUS simulations were performed using both the hybrid angular spectrum (HAS) method and k-Wave. Simulated power deposition patterns were converted to temperature maps using a Pennes' bioheat equation-based thermal solver. Agreement of pressure between the simulation techniques and temperature between the simulation and experimental heating was evaluated. Contributions of scattering and absorption attenuation were considered.

Results: Simulated peak pressures derived using the HAS method exceeded the simulated peak pressures from k-Wave by 1.6 ± 2.7%. The location and FWHM of the peak pressure calculated from HAS and k-Wave showed good agreement. When muscle acoustic absorption value in the simulations was adjusted to approximately 54% of the measured attenuation, the average root-mean-squared error between simulated and experimental spatial-average temperature profiles was 0.046 ± 0.019 °C/W. Mean distance between simulated and experimental COTMs was 3.25 ± 1.37 mm. Transverse FWHMs of simulated sonications were smaller than in in vivo sonications. Longitudinal FWHMs were similar.

Conclusions: Presented results demonstrate agreement between HAS and k-Wave simulations and that FUS simulations can accurately predict focal position and heating for in vivo applications in soft tissue.

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来源期刊
CiteScore
5.90
自引率
12.90%
发文量
153
审稿时长
6-12 weeks
期刊介绍: The International Journal of Hyperthermia
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