Ezebuilo U Ekpono, Ejike D Eze, Afodun M Adam, Udu A Ibiam, Orji U Obasi, Josiah E Ifie, Ejike U Ekpono, Esther U Alum, Sana Noreen, Chinaza G Awuchi, Patrick M Aja
{"title":"南瓜籽油(Cucurbita pepo L.)对曲马多诱导的氧化应激的改善潜力","authors":"Ezebuilo U Ekpono, Ejike D Eze, Afodun M Adam, Udu A Ibiam, Orji U Obasi, Josiah E Ifie, Ejike U Ekpono, Esther U Alum, Sana Noreen, Chinaza G Awuchi, Patrick M Aja","doi":"10.1177/15593258241226913","DOIUrl":null,"url":null,"abstract":"<p><strong>Background of the study: </strong>The increase in the therapeutic use of tramadol in the management of moderate to severe pains in some disease conditions and its unregulated access has led to its associated toxicity and there is little or no information on the protection against its associated toxicity.</p><p><strong>Aim of the study: </strong>Considering the medicinal value of pumpkin seed oil, its availability, and neglected use, it becomes necessary to evaluate the possible potential of the seed oil in tramadol-induced oxidative stress in Wister Albino rats.</p><p><strong>Methods of the study: </strong>This study used fifty-six (56) albino rats to determine the impact of <i>Cucurbita pepo</i> seed oil (CPSO) on tramadol-induced oxidative stress. The rats were grouped into 7. After a week of acclimatization, rats in group 1 (normal control) had access to water and food, while rats in group 2 received 5 mL/Kg (b.w) of normal saline. 100 mg/kg of tramadol (TM) was delivered to groups 3-6 to induce toxicity. The third group (TM control) received no treatment, whilst the other 3 groups (TM-CPSO treatment groups) received 5, 2.5, and 1.5 mL/Kg of CPSO, respectively. Group 7 received only 5 mL/kg CPSO (CPSO group). Similarly, groups 2 through 7 had unrestricted access to food and water for 42 days and received treatments via oral intubation once per day. Indicators of oxidative stress were discovered in the brain homogenate.</p><p><strong>Results: </strong>TM toxicity was demonstrated by a considerable increase (<i>P</i> < .05) in the brain MDA level and a significant drop (<i>P</i> < .05) in the brain GSH level, as well as a significant reduction (<i>P</i> < .05) in GPx, catalase, SOD, GST, and quinone reductase activities.</p><p><strong>Conclusion: </strong>The dose-dependent delivery of CPSO was able to restore not only the activity but also the concentrations of the altered markers.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"22 1","pages":"15593258241226913"},"PeriodicalIF":2.3000,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10793191/pdf/","citationCount":"0","resultStr":"{\"title\":\"Ameliorative Potential of Pumpkin Seed Oil (<i>Cucurbita pepo</i> L.) 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The rats were grouped into 7. After a week of acclimatization, rats in group 1 (normal control) had access to water and food, while rats in group 2 received 5 mL/Kg (b.w) of normal saline. 100 mg/kg of tramadol (TM) was delivered to groups 3-6 to induce toxicity. The third group (TM control) received no treatment, whilst the other 3 groups (TM-CPSO treatment groups) received 5, 2.5, and 1.5 mL/Kg of CPSO, respectively. Group 7 received only 5 mL/kg CPSO (CPSO group). Similarly, groups 2 through 7 had unrestricted access to food and water for 42 days and received treatments via oral intubation once per day. Indicators of oxidative stress were discovered in the brain homogenate.</p><p><strong>Results: </strong>TM toxicity was demonstrated by a considerable increase (<i>P</i> < .05) in the brain MDA level and a significant drop (<i>P</i> < .05) in the brain GSH level, as well as a significant reduction (<i>P</i> < .05) in GPx, catalase, SOD, GST, and quinone reductase activities.</p><p><strong>Conclusion: </strong>The dose-dependent delivery of CPSO was able to restore not only the activity but also the concentrations of the altered markers.</p>\",\"PeriodicalId\":11285,\"journal\":{\"name\":\"Dose-Response\",\"volume\":\"22 1\",\"pages\":\"15593258241226913\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-01-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10793191/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dose-Response\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/15593258241226913\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dose-Response","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/15593258241226913","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Ameliorative Potential of Pumpkin Seed Oil (Cucurbita pepo L.) Against Tramadol-Induced Oxidative Stress.
Background of the study: The increase in the therapeutic use of tramadol in the management of moderate to severe pains in some disease conditions and its unregulated access has led to its associated toxicity and there is little or no information on the protection against its associated toxicity.
Aim of the study: Considering the medicinal value of pumpkin seed oil, its availability, and neglected use, it becomes necessary to evaluate the possible potential of the seed oil in tramadol-induced oxidative stress in Wister Albino rats.
Methods of the study: This study used fifty-six (56) albino rats to determine the impact of Cucurbita pepo seed oil (CPSO) on tramadol-induced oxidative stress. The rats were grouped into 7. After a week of acclimatization, rats in group 1 (normal control) had access to water and food, while rats in group 2 received 5 mL/Kg (b.w) of normal saline. 100 mg/kg of tramadol (TM) was delivered to groups 3-6 to induce toxicity. The third group (TM control) received no treatment, whilst the other 3 groups (TM-CPSO treatment groups) received 5, 2.5, and 1.5 mL/Kg of CPSO, respectively. Group 7 received only 5 mL/kg CPSO (CPSO group). Similarly, groups 2 through 7 had unrestricted access to food and water for 42 days and received treatments via oral intubation once per day. Indicators of oxidative stress were discovered in the brain homogenate.
Results: TM toxicity was demonstrated by a considerable increase (P < .05) in the brain MDA level and a significant drop (P < .05) in the brain GSH level, as well as a significant reduction (P < .05) in GPx, catalase, SOD, GST, and quinone reductase activities.
Conclusion: The dose-dependent delivery of CPSO was able to restore not only the activity but also the concentrations of the altered markers.
Dose-ResponsePHARMACOLOGY & PHARMACY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
CiteScore
4.90
自引率
4.00%
发文量
140
审稿时长
>12 weeks
期刊介绍:
Dose-Response is an open access peer-reviewed online journal publishing original findings and commentaries on the occurrence of dose-response relationships across a broad range of disciplines. Particular interest focuses on experimental evidence providing mechanistic understanding of nonlinear dose-response relationships.